Publication Name	World Journal of Gastroenterology
Manuscript ID	5096
Country	Italy

Received	2013-08-15 07:41
Peer-Review Started	2013-08-15 12:02
To Make the First Decision	2013-09-09 16:46
Return for Revision	2013-09-10 16:43
Revised	2013-11-10 23:43
Second Decision	2014-01-02 11:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-02 12:12
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-23 10:52
Publish the Manuscript Online	2014-02-20 19:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials
Manuscript Source	Invited Manuscript
All Author List	Bruna Scaggiante, Maryam Kazemi, Gabriele Pozzato, Barbara Dapas, Rosella Farra, Mario Grassi, Fabrizio Zanconati and Gabriele Grassi
Funding Agency and Grant Number	Funding Agency Grant Number “Fondazione Cassa di Risparmio of Trieste” “Fondazione Benefica Kathleen Foreman Casali of Trieste” Italian Minister of Instruction, University and Research (MIUR) PRIN 2010-11 Italian Minister of Instruction, University and Research (MIUR) 20109PLMH2
Corresponding Author	Gabriele Grassi, MD, PhD, Department of Life Sciences, University Hospital of Cattinara, Strada di Fiume 447, 34100 Trieste, Italy. ggrassi@units.it
Key Words	Hepatocellular carcinoma; Biochemical markers; Micro-interfering RNA; Epigenetic variations; Tumor stroma; Angiogenic factors
Core Tip	Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The modest efficacy of the therapeutic approaches also depends on the fact that the diagnosis often occurs in the late stages of the disease. Thus, the identification of early markers of onset and progression could be of significant benefit. Here we mainly focus on the latest data pointing the attention towards: (1) biochemical cellular markers; (2) micro-interfering RNA; (3) epigenetic variations; and (4) tumor stroma. The integration of these different lines of investigations should represent promising strategies to identify effective HCC markers.
Publish Date	2014-02-20 19:40
Citation	Scaggiante B, Kazemi M, Pozzato G, Dapas B, Farra R, Grassi M, Zanconati F, Grassi G. Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials. World J Gastroenterol 2014; 20(5): 1268-1288
URL	http://www.wjgnet.com/1007-9327/full/v20/i5/1268.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i5.1268

Full Article (PDF)	WJG-20-1268.pdf
Full Article (Word)	WJG-20-1268.doc
Manuscript File	5096-Review.docx
Answering Reviewers	5096-Answering review(s).pdf
Copyright License Agreement	5096-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5096-Language certificate.pdf
Peer-review Report	5096-Peer review(s).pdf
Scientific Editor Work List	5096-Scientific editor work list.doc