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Articles Published Processes
11/21/2019 8:40:16 AM | Browse: 924 | Download: 1995
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Received |
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2019-09-02 02:07 |
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Peer-Review Started |
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2019-09-02 02:07 |
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To Make the First Decision |
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2019-09-19 06:55 |
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Return for Revision |
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2019-09-20 08:12 |
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Revised |
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2019-10-15 10:33 |
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Second Decision |
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2019-10-28 10:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-01 01:47 |
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Articles in Press |
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2019-11-01 01:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-16 20:10 |
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Typeset the Manuscript |
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2019-11-20 08:12 |
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Publish the Manuscript Online |
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2019-11-21 08:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Xin Liu, Feng-Jiao Li, Yan-Qin Li, Wen Gu, Jing-Ping Li and Jie Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81660596 |
| National Natural Science Foundation of China |
81760733 |
| Application and Basis Research Project of Yunnan China |
2016FD050 |
| Application and Basis Research Project of Yunnan |
2017FF117-013 |
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| Corresponding Author |
Jie Yu, PhD, Professor, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. cz.yujie@gmail.com |
| Key Words |
Metabolomics; Mitochondria; Multivariate statistical analysis; Non-alcoholic fatty liver; Polygonatum kingianum; Ultra-high performance liquid chromatography/mass spectrometry |
| Core Tip |
We identified the molecular mechanism behind the mitochondrial regulatory action of Polygonatum kingianum (PK) against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats using an integrated mitochondrial metabolomic method. The results indicated that PK can alleviate HFD-induced NAFLD by regulating riboflavin metabolism, increasing flavin mononucleotide content and further improving mitochondrial functions. PK as a promising mitochondrial regulator/nutrient can alleviate NAFLD-associated diseases. |
| Publish Date |
2019-11-21 08:40 |
| Citation |
Yang XX, Wei JD, Mu JK, Liu X, Li FJ, Li YQ, Gu W, Li JP, Yu J. Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease. World J Gastroenterol 2019; 25(43): 6404-6415 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i43/6404.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i43.6404 |
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