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Articles Published Processes
9/12/2014 8:40:00 PM | Browse: 766 | Download: 765
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Received |
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2013-08-15 07:49 |
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Peer-Review Started |
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2013-08-15 08:07 |
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To Make the First Decision |
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2013-09-09 16:46 |
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Return for Revision |
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2013-09-10 16:42 |
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Revised |
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Second Decision |
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2013-09-29 10:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2013-09-29 21:50 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2013-10-14 13:10 |
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Typeset the Manuscript |
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2013-10-17 15:35 |
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Publish the Manuscript Online |
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2013-11-08 14:06 |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Expression and significance of Musashi-1 in gastric cancer and precancerous lesions
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Manuscript Source |
Invited Manuscript |
All Author List |
Rong-Guang Kuang, Yan Kuang, Qing-Feng Luo, Cheng-Jun Zhou, Rui Ji and Jian-Wen Wang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Jinan Science and Technology Bureau for Independent Innovation Projects of Universities and Research Institutes in Jinan city, China, |
201102060 |
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Corresponding Author |
Qing-Feng Luo, MD, Vice Professor, Vice Chief, Department of Gastroenterology, Beijing Hospital, Ministry of Health, Dahua Rd.1#, DongDan, Dongcheng District, Beijing 100730, China. luoqf2000@126.com |
Key Words |
Musashi-1; Stem cells; Gastric cancer; Precancerous lesions; Immunohistochemistry. |
Core Tip |
Gastric cancer (GC) is currently thought to be a disease originating in stem cells. We detected expression of stem cell marker Musashi-1 (Msi-1) and proliferating cell nuclear antigen (PCNA) in intestinal-type GC and precancerous lesions. Expression of Msi-1 and PCNA in precancerous lesions was significantly higher than in normal mucosa, but lower than in intestinal-type GC. Msi-1 expression in GC tissues was correlated with lymph node metastasis and tumor node metastasis stage. These results suggest that expansion of Msi-1-positive cells is an early event in gastric carcinogenesis and may be involved in invasion and metastasis of GC. |
Publish Date |
2013-11-08 14:06 |
Citation |
Kuang RG, Kuang Y, Luo QF, Zhou CJ, Ji R, Wang JW. Expression and significance of Musashi-1 in gastric cancer and precancerous lesions. World J Gastroenterol 2013; 19(39): 6637-6644 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i39/6637.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i39.6637 |
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