Publication Name	World Journal of Gastroenterology
Manuscript ID	5099
Country	China

Received	2013-08-15 07:49
Peer-Review Started	2013-08-15 08:07
To Make the First Decision	2013-09-09 16:46
Return for Revision	2013-09-10 16:42
Revised
Second Decision	2013-09-29 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-29 21:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-14 13:10
Typeset the Manuscript	2013-10-17 15:35
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Expression and significance of Musashi-1 in gastric cancer and precancerous lesions
Manuscript Source	Invited Manuscript
All Author List	Rong-Guang Kuang, Yan Kuang, Qing-Feng Luo, Cheng-Jun Zhou, Rui Ji and Jian-Wen Wang
Funding Agency and Grant Number	Funding Agency Grant Number Jinan Science and Technology Bureau for Independent Innovation Projects of Universities and Research Institutes in Jinan city, China, 201102060
Corresponding Author	Qing-Feng Luo, MD, Vice Professor, Vice Chief, Department of Gastroenterology, Beijing Hospital, Ministry of Health, Dahua Rd.1#, DongDan, Dongcheng District, Beijing 100730, China. luoqf2000@126.com
Key Words	Musashi-1; Stem cells; Gastric cancer; Precancerous lesions; Immunohistochemistry.
Core Tip	Gastric cancer (GC) is currently thought to be a disease originating in stem cells. We detected expression of stem cell marker Musashi-1 (Msi-1) and proliferating cell nuclear antigen (PCNA) in intestinal-type GC and precancerous lesions. Expression of Msi-1 and PCNA in precancerous lesions was significantly higher than in normal mucosa, but lower than in intestinal-type GC. Msi-1 expression in GC tissues was correlated with lymph node metastasis and tumor node metastasis stage. These results suggest that expansion of Msi-1-positive cells is an early event in gastric carcinogenesis and may be involved in invasion and metastasis of GC.
Publish Date	2013-11-08 14:06
Citation	Kuang RG, Kuang Y, Luo QF, Zhou CJ, Ji R, Wang JW. Expression and significance of Musashi-1 in gastric cancer and precancerous lesions. World J Gastroenterol 2013; 19(39): 6637-6644
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6637.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6637

Full Article (PDF)	WJG-19-6637.pdf
Manuscript File	5099-Review.doc
Answering Reviewers	5099-Answering Reviewers.pdf
Copyright License Agreement	5099-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5099-Language certificate.PDF
Peer-review Report	5099-Peer review(s).pdf
Scientific Editor Work List	5099-Scientific editor work list.doc