Publication Name	World Journal of Gastroenterology
Manuscript ID	5102
Country	China

Received	2013-08-15 08:00
Peer-Review Started	2013-08-15 14:19
To Make the First Decision	2013-09-09 16:47
Return for Revision	2013-09-10 16:50
Revised	2013-09-29 21:44
Second Decision	2013-10-14 09:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-14 13:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-12 05:15
Typeset the Manuscript	2013-12-20 17:18
Publish the Manuscript Online	2014-01-14 20:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN
Manuscript Source	Invited Manuscript
All Author List	Qi Xue, Kai Sun, Hai-Jun Deng, Shang-Tong Lei, Jing-Qing Dong and Guo-Xin Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81101896 National Research Foundation for Doctoral Program of Higher Education of China 20124433110010
Corresponding Author	Kai Sun, PhD, Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China. sunkai9602@sina.com
Key Words	Colorectal carcinoma; miR-221; Phosphatase and tensin homolog deleted on chromosome 10; Radiosensitivity
Core Tip	Previous studies have shown that miRNA (miR)-221 expression is elevated in radioresistant colorectal carcinoma (CRC) cells; however, it is unknown whether and how miR-221 controls cellular response to irradiation. We demonstrated that knockdown of miR-221 upregulated phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression, and PTEN was identified as a direct target of miR-221 in CRC. Upregulated PTEN expression suppressed AKT activity and increased radiation-induced cell death, enhancing radiosensitivity in CRC cells. This study provides evidence for antioncogenic activity of anti-miR-221 in the irradiation of CRC and may be a useful biomarker or therapeutic target in CRC.
Publish Date	2014-01-14 20:11
Citation	Xue Q, Sun K, Deng HJ, Lei ST, Dong JQ, Li GX. Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN. World J Gastroenterol 2013; 19(48): 9307-9317
URL	http://www.wjgnet.com/1007-9327/full/v19/i48/9307.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i48.9307

Full Article (PDF)	WJG-19-9307.pdf
Manuscript File	5102-Review.doc
Answering Reviewers	5102-Answering reviewers.pdf
Copyright License Agreement	5102-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5102-Language certificate.PDF
Peer-review Report	5102-Peer review(s).pdf
Scientific Editor Work List	5102-Scientific editor work list.doc