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Articles Published Processes
2/27/2020 7:06:19 AM | Browse: 911 | Download: 1873
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Received |
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2019-08-27 03:48 |
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Peer-Review Started |
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2019-08-27 03:50 |
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To Make the First Decision |
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2019-10-21 02:08 |
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Return for Revision |
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2019-10-21 07:20 |
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Revised |
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2019-12-27 00:14 |
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Second Decision |
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2020-01-05 09:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-06 20:08 |
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Articles in Press |
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2020-01-06 20:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-01-10 00:26 |
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Typeset the Manuscript |
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2020-02-21 03:06 |
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Publish the Manuscript Online |
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2020-02-27 07:06 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Comparison between the therapeutic effects of differentiated and undifferentiated Wharton's jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen-Yuan Hsiao, Tien-Hua Chen, Ben-Shian Huang, Po-Han Chen, Cheng-Hsi Su, Jia-Fwu Shyu and Pei-Jiun Tsai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Taipei Veterans General Hospital |
V106B-024 |
| Yen Tjing Ling Medical Foundation |
CI-106-20 |
| Taiwan Ministry of Science and Technology |
MOST 105-2314-B-010-010-MY3 |
| Cheng Hsin General Hospital |
CY10716 |
| Taiwan Ministry of Science and Technology |
MOST 106-2314-B-010-009 |
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| Corresponding Author |
Pei-Jiun Tsai, MD, PhD, Assistant Professor, Attending Doctor, Surgeon, Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, 201 Shih-Pai Road Section 2, Taipei 112, Taiwan. pjtsai@vghtpe.gov.tw |
| Key Words |
Human Wharton’s jelly mesenchymal stem cell; Insulin-producing cells; Diabetes mellitus; Differentiation; Regeneration therapy; Anti-inflammatory |
| Core Tip |
The therapeutic mechanism of differentiated and undifferentiated human Wharton’s Jelly mesenchymal stem cells in streptozotocin-induced diabetic rats may be different. Differentiated insulin producing cells can significantly improve blood glucose levels due to continuously secretion insulin by the transplanted cells that survived in the islets of diabetic rats. Transplantation of undifferentiated human Wharton’s Jelly mesenchymal stem cells can significantly improve insulitis and re-balance the inflammatory condition with only a slight improvement in blood glucose levels. The results of this study will provide basic and essential information for future application of cell regenerative therapy in diabetic patients. |
| Publish Date |
2020-02-27 07:06 |
| Citation |
Hsiao CY, Chen TH, Huang BS, Chen PH, Su CH, Shyu JF, Tsai PJ. Comparison between the therapeutic effects of differentiated and undifferentiated Wharton’s jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes. World J Stem Cells 2020; 12(2): 139-151 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i2/139.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i2.139 |
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