Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	51277
Country	United States

Received	2019-09-05 23:25
Peer-Review Started	2019-09-05 23:25
To Make the First Decision	2019-10-14 01:03
Return for Revision	2019-10-14 03:55
Revised	2019-11-04 13:00
Second Decision	2019-12-11 09:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-12-15 04:57
Articles in Press	2019-12-15 04:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-29 06:17
Publish the Manuscript Online	2020-01-16 10:11

ISSN	1948-9366 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Hyponatremia is associated with more severe biliary disease
Manuscript Source	Unsolicited Manuscript
All Author List	Michael John Zobel and Lygia Stewart
ORCID	Author(s) ORCID Number Michael John Zobel http://orcid.org/0000-0002-8082-512X Lygia Stewart http://orcid.org/0000-0003-2778-7950
Funding Agency and Grant Number
Corresponding Author	Lygia Stewart, MD, Professor, Surgeon, Department of Surgery, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94143, United States. lygia.stewart@va.gov
Key Words	Hyponatremia; Biliary disease; Cholecystitis; Cholangitis; Sodium; Sepsis
Core Tip	This unique study is the first to explore, with such granularity, the relationship between biliary disease and sodium. No prior studies have examined specific culture and clinical data. It demonstrates an inverse, independent correlation between illness severity and sodium. Culture data demonstrate that sodium decreases as infection ascends from gallstone colonization to bactibilia to bacteremia. Patient comorbidity and gangrenous changes also independently correlate with sodium on multivariate analysis. Sodium level is an important clinical indicator of disease severity for patients with biliary disease.
Publish Date	2020-01-16 10:11
Citation	Zobel MJ, Stewart L. Hyponatremia is associated with more severe biliary disease. World J Gastrointest Surg 2020; 12(2): 45-54
URL	https://www.wjgnet.com/1948-9366/full/v12/i2/45.htm
DOI	https://dx.doi.org/10.4240/wjgs.v12.i2.45

Full Article (PDF)	WJGS-12-45.pdf
Full Article (Word)	WJGS-12-45.docx
Manuscript File	51277-Review.docx
Answering Reviewers	51277-Answering reviewers.pdf
Audio Core Tip	51277-Audio core tip.mp3
Biostatistics Review Certificate	51277-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	51277-Conflict-of-interest statement.pdf
Copyright License Agreement	51277-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	51277-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	51277-Institutional review board statement.pdf
Peer-review Report	51277-Peer-review(s).pdf
Scientific Misconduct Check	51277-Scientific misconduct check.pdf
Scientific Editor Work List	51277-Scientific editor work list.pdf
CrossCheck Report	51277-CrossCheck Report.pdf