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Articles Published Processes
1/14/2020 10:51:49 AM | Browse: 963 | Download: 1128
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Received |
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2019-09-08 20:13 |
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Peer-Review Started |
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2019-09-08 20:13 |
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To Make the First Decision |
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2019-10-15 00:28 |
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Return for Revision |
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2019-10-15 01:44 |
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Revised |
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2019-10-26 02:19 |
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Second Decision |
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2019-12-06 03:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-12-06 19:11 |
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Articles in Press |
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2019-12-06 19:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-01-10 02:17 |
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Publish the Manuscript Online |
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2020-01-14 10:51 |
| ISSN |
2220-3230 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Review |
| Article Title |
Therapeutics administered during ex vivo liver machine perfusion: An overview
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Julianna E Buchwald, Jing Xu, Adel Bozorgzadeh and Paulo N Martins |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Paulo N Martins, MD, PhD, Assistant Professor, Attending Doctor, Surgeon, Department of Surgery, Transplant Division, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, United States. paulo.martins@umassmemorial.org |
| Key Words |
Therapeutics; Liver transplantation; Ex vivo machine perfusion; Ischemia reperfusion injury; Organ preservation; Extended criteria donors |
| Core Tip |
The use of extended criteria donors has increased the donor pool of available livers for transplant but has also introduced other hurdles in protecting these vulnerable organs against ischemia-reperfusion injury (IRI). Current basic science research is aimed at mitigating the effects of IRI during the transplantation process by administering therapeutics during ex vivo liver machine perfusion. Of interest include therapeutics aimed at evoking the RNA interference pathway, utilizing defatting cocktails, and administering classes of agents such as vasodilators and anti-inflammatory drugs to reduce the damage of IRI following liver procurement and transplantation for ultimate preservation of the organ. |
| Publish Date |
2020-01-14 10:51 |
| Citation |
Buchwald JE, Xu J, Bozorgzadeh A, Martins PN. Therapeutics administered during ex vivo liver machine perfusion: An overview. World J Transplant 2020; 10(1): 1-14 |
| URL |
https://www.wjgnet.com/2220-3230/full/v10/i1/1.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v10.i1.1 |
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