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Articles Published Processes
4/15/2020 12:00:00 PM | Browse: 645 | Download: 1038
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Received |
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2019-09-19 04:02 |
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Peer-Review Started |
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2019-09-19 04:02 |
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To Make the First Decision |
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2019-10-21 02:20 |
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Return for Revision |
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2019-10-21 07:36 |
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Revised |
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2019-12-10 03:07 |
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Second Decision |
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2019-12-21 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-12-23 17:24 |
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Articles in Press |
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2019-12-23 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-01-18 06:17 |
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Publish the Manuscript Online |
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2020-04-15 12:00 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Primary tumor location and survival in colorectal cancer: A retrospective cohort study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Himani Aggarwal, Kristin M Sheffield, Li Li, David Lenis, Rachael Sorg, Afsaneh Barzi and Rebecca Miksad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Himani Aggarwal, MPhil, PhD, Research Scientist, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46225, United States. aggarwal_himani@lilly.com |
| Key Words |
Bevacizumab; Cetuximab; Cohort study; Colorectal neoplasms; Electronic health records; Prognosis |
| Core Tip |
Primary tumor location is a prognostic factor for metastatic colorectal cancer (mCRC). Post hoc analyses of randomized clinical trials, including FIRE-3 and CALGB/SWOG 80405, suggest that primary tumor location is also predictive of survival benefit with cetuximab and bevacizumab in mCRC patients. This analysis of a large cohort of real-world patients with KRAS wild-type mCRC who received first-line treatment with cetuximab or bevacizumab with 5-fluorouracil-based chemotherapy found a prognostic effect of primary tumor location but not a predictive effect, possibly due to differences between patients in real world clinical practice versus clinical trial settings. |
| Publish Date |
2020-04-15 12:00 |
| Citation |
Aggarwal H, Sheffield KM, Li L, Lenis D, Sorg R, Barzi A, Miksad R. Primary tumor location and survival in colorectal cancer: A retrospective cohort study. World J Gastrointest Oncol 2020; 12(4): 405-423 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i4/405.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i4.405 |
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