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Articles Published Processes
11/21/2019 8:40:16 AM | Browse: 879 | Download: 2690
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Received |
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2019-09-19 17:51 |
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Peer-Review Started |
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2019-09-19 17:54 |
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To Make the First Decision |
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2019-10-14 09:33 |
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Return for Revision |
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2019-10-16 01:47 |
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Revised |
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2019-10-19 18:15 |
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Second Decision |
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2019-10-31 11:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-01 02:41 |
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Articles in Press |
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2019-11-01 02:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-15 08:20 |
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Typeset the Manuscript |
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2019-11-20 08:12 |
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Publish the Manuscript Online |
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2019-11-21 08:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Xue Zhang, Yu Zhang, Geng Qin, Kai-Min Li, Wei Wei, Su-Yun Li and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Technology Support Program during “12 th Five-Year Plan” Period of China |
2014BAI08B00 |
| Research projects on biomedical transformation of China-Japan Friendship Hospital |
No.PYBZ1815 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Fecal metabolite; Irritable bowel syndrome; Amino acids; Organic acids; Short chain fatty acids; Visceral hypersensitivity |
| Core Tip |
We comprehensively assessed the clinical and psychological characteristics of irritable bowel syndrome with predominant diarrhea (IBS-D) patients, visceral sensitivity, and fecal metabolites. As expected, these data confirmed metabolite compositions were different in subjects with or without IBS-D and the levels of some metabolites were significantly correlated with IBS Symptom Severity System score, visceral sensitivity, and the severity or frequency of abdominal pain. Furthermore, a potential biomarker panel was identified to correlate with the symptom severity of IBS-D. These preliminary findings provide some clues for IBS-D pathogenesis and for the search for biomarkers in symptom severity. |
| Publish Date |
2019-11-21 08:40 |
| Citation |
Zhang WX, Zhang Y, Qin G, Li KM, Wei W, Li SY, Yao SK. Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(43): 6416-6429 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i43/6416.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i43.6416 |
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