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Articles Published Processes
1/16/2020 10:11:20 AM | Browse: 710 | Download: 1118
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Received |
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2019-09-27 17:45 |
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Peer-Review Started |
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2019-09-27 17:46 |
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To Make the First Decision |
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2019-10-25 02:57 |
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Return for Revision |
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2019-10-31 01:05 |
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Revised |
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2019-11-24 11:15 |
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Second Decision |
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2019-12-11 09:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-12-15 04:54 |
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Articles in Press |
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2019-12-15 04:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-12-29 06:55 |
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Publish the Manuscript Online |
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2020-01-16 10:11 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Retrospective cohort study of statin therapy effect on resected colorectal liver metastases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Edward Alabraba, Hussain Ibrahim, Adina Olaru, Iain Cameron and Dhanny Gomez |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dhanny Gomez, FRCS, Surgeon, Department of Hepatobiliary Surgery and Pancreatic Surgery, Queen’s Medical Centre, Nottingham University Hospitals NHS Trust, E Floor, West Block, Queen’s Medical Centre, Derby Road, Nottingham NG7 2UH, United Kingdom. dhannygomez@hotmail.com |
| Key Words |
Colorectal liver metastases; Statin; Liver resection; Chemoprevention; Tumour biology; Survival |
| Core Tip |
Colorectal liver metastases (CRLM) develop in 25%-30% of patients with colorectal cancer and disease prevalence has increased with expansion in the at-risk older age group. The need for chemoprevention to inhibit carcinogenesis is an attractive option that has shown promise in patients at high risk of developing CRLM. Observational studies have shown statins are promising chemopreventive agents but no data exist specifically for CRLM. Statins represent a well-established drug group whose pharmacodynamic properties are familiar to clinicians and if they demonstrate effectiveness as chemoprevention for CRLM, repurposing statins for this use will be more cost- and time- effective compared to developing new agents. |
| Publish Date |
2020-01-16 10:11 |
| Citation |
Alabraba E, Ibrahim H, Olaru A, Cameron I, Gomez D, Nottingham HPB Surgery Group. Retrospective cohort study of statin therapy effect on resected colorectal liver metastases. World J Gastrointest Surg 2020; 12(2): 34-44 |
| URL |
https://www.wjgnet.com/1948-9366/full/v12/i2/34.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v12.i2.34 |
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