| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Wen, Hong-Yu Sun, Zhen Tan, Ruo-Hong Liu, Shang-Qing Huang, Guang-Yu Chen, Hao Qi and Li-Jun Tang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81772001 |
| the National Clinical Key Subject of China |
41792113 |
| the Technology Plan Program of Sichuan Provence |
2015SZ0229, 2016HH0067, 2018JY0041 and 2019YJ0277 |
|
| Corresponding Author |
Li-Jun Tang, MD, PhD, Chief Doctor, Professor, Department of General Surgery & Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. tanglj2016@163.com |
| Key Words |
Abdominal paracentesis drainage; Severe acute pancreatitis; Myocardial injury; High mobility group box 1; Nicotinamide adenine dinucleotide phosphate oxidase; Oxidative stress |
| Core Tip |
In the present study, we provided the first evidence that abdominal paracentesis drainage (APD) treatment exerts beneficial effect on SAP-associated cardiac injury. Our key findings are that (1) APD treatment decreases the serum levels of cardiac enzymes and improves cardiac function; (2) APD treatment alleviates cardiac oxidative stress and accompanied cardiomyocyte apoptosis; and (3) the beneficial effects of APD treatment in ameliorating severe acute pancreatitis-associated cardiac injury are due to the inhibition of oxidative damage via downregulating high mobility group box 1 mediated nicotinamide adenine dinucleotide phosphate oxidase expression. Our data manifest that APD is a promising treatment in severe acute pancreatitis-associated cardiac injury. |
| Publish Date |
2020-01-07 07:47 |
| Citation |
Wen Y, Tan Z, Liu RH, Huang SQ, Chen GY, Qi H, Sun HY, Tang LJ. Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress. World J Gastroenterol 2020; 26(1): 35-54 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i1/35.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i1.35 |
