Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	5151
Country	United States

Received	2013-08-18 10:48
Peer-Review Started	2013-08-19 13:22
To Make the First Decision	2013-09-29 10:36
Return for Revision	2013-09-30 09:11
Revised
Second Decision	2013-12-10 16:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-11 09:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-27 15:26
Publish the Manuscript Online	2014-01-27 17:26

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Clinical update for the diagnosis and treatment of Clostridium difficile infection
Manuscript Source	Invited Manuscript
All Author List	Edward C Oldfield Ⅳ, Edward C Oldfield Ⅲ and David A Johnson
Funding Agency and Grant Number
Corresponding Author	David A Johnson, MD, Professor of Medicine, Chief of Gastroenterology, Division of Gastroenterology, Division of Infectious Disease, Department of Internal Medicine, Eastern Virginia Medical School, 4111 Monarch Way, Norfolk, VA 23508, United States. dajevms@aol.com
Key Words	Clostridium difficile; Antibiotic-associated diarrhea; Fidaxomicin; Rifaximin; Fecal transplantation; Probiotics
Core Tip	This paper seeks explore the treatment and diagnosis of Clostridium difficile infection (CDI) through an extensive literature review of available laboratory techniques and new treatment options. For diagnosis, this includes the glutamate dehydrogenase of stool and polymerase chain reaction for gene toxin. For treatment this includes guidelines based on severity, newer antibiotics for the treatment of CDI, fecal microbiota transplantation, and several new experimental treatment options. Finally, this manuscript offers suggested clinical guidelines for how to diagnose and treat CDI.
Publish Date	2014-01-27 17:26
Citation	Oldfield Ⅳ EC, Oldfield Ⅲ EC, Johnson DA. Clinical update for the diagnosis and treatment of Clostridium difficile infection.World J Gastrointest Phar-macol Ther 2014; 5(1): 1-26
URL	http://www.wjgnet.com/2150-5349/full/v5/i1/1.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v5.i1.1

Full Article (PDF)	WJGPT-5-1.pdf
Full Article (Word)	WJGPT-5-1.doc
Manuscript File	5151-Review.docx
Answering Reviewers	5151-Answering reviewers.pdf
Copyright License Agreement	5151-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130817211421.docx
Peer-review Report	5151-Peer review(s).pdf
Scientific Editor Work List	5151-Scientific editor work list.doc