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Articles Published Processes
3/12/2020 11:28:25 AM | Browse: 669 | Download: 1192
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Received |
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2019-09-27 14:26 |
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Peer-Review Started |
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2019-09-27 14:26 |
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To Make the First Decision |
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2019-10-21 02:33 |
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Return for Revision |
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2019-10-25 07:16 |
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Revised |
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2019-12-08 02:46 |
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Second Decision |
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2019-12-21 03:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-12-23 22:33 |
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Articles in Press |
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2019-12-23 22:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-01-17 06:58 |
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Publish the Manuscript Online |
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2020-03-12 11:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kei Kimura, Naohito Beppu, Hiroshi Doi, Kozo Kataoka, Tomoki Yamano, Motoi Uchino, Masataka Ikeda, Hiroki Ikeuchi and Naohiro Tomita |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kei Kimura, MD, PhD, Assistant Professor, Doctor, Division of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 661-8501, Hyogo, Japan. k-kimura@hyo-med.ac.jp |
| Key Words |
Preoperative chemoradiotherapy; Rectal cancer; Irinotecan; Tegafur/gimeracil/oteracil; Neoadjuvant chemoradiotherapy; Radiation therapy |
| Core Tip |
Lower advanced rectal cancer located within 8 cm of the anal verge carries a higher risk of local recurrence. The aim of this single-center retrospective study was to assess the clinical outcomes of patients with locally advanced rectal cancer treated preoperative chemoradiotherapy using tegafur/gimeracil/oteracil plus irinotecan. Grade 3 or 4 toxicity was mild and led to good relative dose intensity with on-schedule treatment. Also, we investigated the risk factors for local recurrence-free survival and relapse-free survival. Multivariate analysis detected no factors for local recurrence-free survival. Our study confirmed good compliance and favorable tumor regression. |
| Publish Date |
2020-03-12 11:28 |
| Citation |
Kimura K, Beppu N, Doi H, Kataoka K, Yamano T, Uchino M, Ikeda M, Ikeuchi H, Tomita N. Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer. World J Gastrointest Oncol 2020; 12(3): 311-322 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i3/311.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i3.311 |
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