| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Tailored eradication vs empirical bismuth-containing quadruple therapy as first-line Helicobacter eradication: A comparative, open trial
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Youn I Choi, Jun Won Chung, Dong Kyun Park, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim and Ja Young Seo |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Jun Won Chung, MD, PhD, Associate Professor, Doctor, Doctor, Division of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, 21, Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, South Korea. junwonchung@hanmail.net |
| Key Words |
Helicobacter pylori; Eradication; Tailored; Empirical; Quadruple; |
| Core Tip |
Few studies have compared the efficacy and safety profile of a tailored eradication (TR) strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy (EBQT) as first-line eradication for Helicobacter pylori infection in Korean patients.
In this prospective, open-label, comparative study results, the first-line eradication rate of H. pylori did not statistically differ between the strategy of TR and EBQT. However, the rate of eradication-related side effects was significantly lower in TR than EBQT strategy.
TR H. pylori eradication using DPO-PCR may be equally efficacious, with less treatment-related complications, compared to EBQT in Korea, where clarithromycin resistance is high. |
| Publish Date |
2019-12-14 11:18 |
| Citation |
Choi YI, Chung JW, Park DK, Kim KO, Kwon KA, Kim YJ, Seo JY. Tailored eradication vs empirical bismuth-containing quadruple therapy as first-line Helicobacter eradication: A comparative, open trial. World J Gastroenterol 2019; 25(46): 6743-6751 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i46/6743.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i46.6743 |
