Publication Name	World Journal of Gastroenterology
Manuscript ID	5171
Country	China

Received	2013-08-20 08:43
Peer-Review Started	2013-08-20 19:25
To Make the First Decision	2013-11-13 15:21
Return for Revision	2013-11-14 15:05
Revised	2013-12-07 16:16
Second Decision	2014-01-08 18:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-08 18:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-14 10:42
Typeset the Manuscript	2014-02-19 14:51
Publish the Manuscript Online	2014-02-26 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Autobiography
Article Title	ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats
Manuscript Source	Invited Manuscript
All Author List	Yu Chen, Chun Lin, Ying Tang, Ai-Qin Chen, Cui-Ying Liu and Da-Li Lu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Fund of Fujian Province C0910595 Natural Science Fund of Fujian Province 2012J05053 Science Fund and Doctor Initial Fund of FMU 09ZD009 Science Fund and Doctor Initial Fund of FMU 2010BS008
Corresponding Author	Chun Lin, MD, Professor, Chief, Laboratory for Pain Research, Key Laboratory of Brain Aging and Neurodegenerative Diseases, Center for Neuroscience Research, Department of Physiology and Pathophysiology, Fujian Medical University, No. 1 Xueyuan Road, Shangjie Zhen, Minhou County, Fuzhou 350108, Fujian Province, China. chunlin77550@126.com
Key Words	Abdominal withdrawal reflex; Electromyography; Hyperpolarization-activated cyclic nucleotide-gated channel; Visceral hypersensitivity; ZD 7288; Irritable bowel syndrome
Core Tip	Intrathecal administration of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated channel blocker, significantly inhibited electromyographic responses and abdominal withdrawal reflex scores and significantly increased pain thresholds in rats with chronic visceral hypersensitivity. These results are important for clinicians and the fundamental scientific community and provide scientific evidence for ZD 7288 as a novel treatment for visceral pain in irritable bowel syndrome.
Publish Date	2014-02-26 11:18
Citation	Chen Y, Lin C, Tang Y, Chen AQ, Liu CY, Lu DL. ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol 2014; 20(8): 2091-2097
URL	http://www.wjgnet.com/1007-9327/full/v20/i8/2091.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i8.2091

Full Article (PDF)	WJG-20-2091.pdf
Full Article (Word)	WJG-20-2091.doc
Manuscript File	5171-Review.doc
Answering Reviewers	5171-Answering reviewers.pdf
Copyright License Agreement	5171-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	5171-Language certificate.pdf
Peer-review Report	5171-Peer review(s).pdf
Scientific Editor Work List	5171-Scientific editor work list.doc