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Articles Published Processes
11/28/2019 10:38:52 AM | Browse: 1123 | Download: 1429
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Received |
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2019-10-10 05:48 |
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Peer-Review Started |
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2019-10-10 05:48 |
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To Make the First Decision |
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Return for Revision |
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2019-11-10 05:08 |
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Revised |
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2019-11-20 07:51 |
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Second Decision |
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2019-11-22 13:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-22 22:38 |
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Articles in Press |
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2019-11-22 22:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-28 02:51 |
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Publish the Manuscript Online |
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2019-11-28 10:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Seol-Hee Han, Ji-Su Mo, Won-Cheol Park and Soo‐Cheon Chae |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Soo‐Cheon Chae, PhD, Professor, Department of Pathology, School of Medicine, Wonkwang University, 460 Iksandae-ro, Chonbuk 54538, South Korea. chaesc@wku.ac.kr |
| Key Words |
MicroRNA 375; Metadherin; Mitogen-activated protein kinase; Angiogenesis; Cell proliferation; Colorectal cancer |
| Core Tip |
The microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) tissues. In this study, we investigated that metadherin (MTDH) is a direct target gene of MIR375 and that MTDH expression levels were upregulated in CRC tissues. Upregulated MTDH expression levels were found to inhibit NF-κB inhibitor alpha expression, which further upregulated NFKB1 and RELA expression in CRC cells. MIR375 also regulate MTDH-mediated BRAF-MAPK and PIK3CA-AKT signal pathways in CRC cells. Consequently, MIR375 regulates cell proliferation, cell migration, and angiogenesis by suppressing MTDH expression in CRC progression. |
| Publish Date |
2019-11-28 10:38 |
| Citation |
Han SH, Mo JS, Park WC, Chae SC. Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling. World J Gastroenterol 2019; 25(44): 6495-6507 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i44/6495.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i44.6495 |
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