Publication Name	World Journal of Gastroenterology
Manuscript ID	5181
Country	Egypt

Received	2013-08-20 09:47
Peer-Review Started	2013-08-20 21:40
To Make the First Decision	2013-09-09 16:54
Return for Revision	2013-09-15 19:18
Revised	2013-09-24 11:07
Second Decision	2013-11-04 17:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-05 10:10
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-19 21:07
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Topic Highlights
Article Title	Burden of pediatric hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Mortada Hassan El-Shabrawi and Naglaa Mohamed Kamal
Funding Agency and Grant Number
Corresponding Author	Mortada Hassan El-Shabrawi, MD, Professor of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, 3 Nablos Street, Off Shehab Street, Mohandesseen, Giza 12411, Egypt. melshabrawi@medicine.cu.edu.eg
Key Words	Hepatitis C virus; Burden; Genotypes; Cost; Pediatrics
Core Tip	Hepatitis C virus (HCV) is a worldwide health burden infecting up to 5.8% of children in some developing countries with thousands of annual new infections. HCV vaccine is illusive, but understanding immune mechanisms in patients who cleared infection may be crucial. The pediatric standard of care treatment is pegylated interferon-飦? plus ribavirin for 24-48 wk. The new oral direct acting antivirals need further evaluation in children. Interleukin-28B polymorphisms have been associated with treatment response and spontaneous clearance of vertical HCV infection. The worldwide economic burden of HCV is estimated to be hundreds of millions United States dollars/year. The emotional burden is difficult to estimate.
Publish Date	2013-12-11 16:13
Citation	El-Shabrawi MH, Kamal NM. Burden of pediatric hepatitis C. World J Gastroenterol 2013; 19(44): 7880-7888
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/7880.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.7880

Full Article (PDF)	WJG-19-7880.pdf
Manuscript File	5181-Review.docx
Answering Reviewers	5181-Answering reviewers.pdf
Copyright License Agreement	5181-Copyright assignment.pdf
Peer-review Report	5181-Peer review(s).pdf
Scientific Editor Work List	5181-Scientific editor work list.doc