Publication Name	World Journal of Clinical Cases
Manuscript ID	51881
Country	China

Received	2019-10-07 17:19
Peer-Review Started	2019-10-07 17:20
To Make the First Decision
Return for Revision	2019-11-13 06:38
Revised	2019-11-18 13:19
Second Decision	2019-11-29 09:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-11-30 03:29
Articles in Press	2019-11-30 03:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-12-17 01:22
Typeset the Manuscript	2020-01-02 08:48
Publish the Manuscript Online	2020-01-07 01:54

ISSN	2307-8960 (online)
Open Access
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Obstetrics & Gynecology
Manuscript Type	Case Control Study
Article Title	Oncogenic role of Tc17 cells in cervical cancer development
Manuscript Source	Unsolicited Manuscript
All Author List	Zun-Sheng Zhang, Ying Gu, Bing-Gang Liu, Hong Tang, Yu Hua and Jun Wang
ORCID	Author(s) ORCID Number Zun-Sheng Zhang http://orcid.org/0000-0002-9013-5536 Ying Gu http://orcid.org/0000-0002-6499-6738 Bing-Gang Liu http://orcid.org/0000-0001-8927-5200 Hong Tang http://orcid.org/0000-0002-5933-8909 Yu Hua http://orcid.org/0000-0002-8230-2920 Jun Wang http://orcid.org/0000-0002-3726-3125
Funding Agency and Grant Number
Corresponding Author	Jun Wang, MSc, Attending Doctor, Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, No. 358, Datong Road, Gaoqiao Town, Pudong New Area, Shanghai 200120, China. wanchuang3069629@163.com
Key Words	Cervical cancer; Tc17 cells; Interleukin-17; Cancer development; Biological function; Oncogenic role
Core Tip	Inflammation contributes to cancer development. Here we find that cervical cancer-elicited inflammation increases Tc17-polarizing cytokine production, which attenuates the cytotoxic CD8+ T cell development. The high amount of interleukin-17 production by Tc17 cells leads to CXCL12 upregulation and cancer cell migration. Consistent with the oncogenic role of Tc17 cells in cancer development, the ratio of cancer-infiltrating Tc17 is highly associated with poor prognosis of patients with cervical cancers. Our data thus demonstrate that Tc17 cells can be induced in cervical cancers and serve as a meaningful index in the prognosis of patients with cervical cancer.
Publish Date	2020-01-07 01:54
Citation	Zhang ZS, Gu Y, Liu BG, Tang H, Hua Y, Wang J. Oncogenic role of Tc17 cells in cervical cancer development. World J Clin Cases 2020; 8(1): 11-19
URL	https://www.wjgnet.com/2307-8960/full/v8/i1/11.htm
DOI	https://dx.doi.org/10.12998/wjcc.v8.i1.11

Full Article (PDF)	WJCC-8-11.pdf
Full Article (Word)	WJCC-8-11.docx
STROBE Statement	51881-STROBE-Statement-revision.pdf
Manuscript File	51811-Review-Ma JY.docx
Answering Reviewers	51881-Answering reviewers.pdf
Audio Core Tip	51881-Audio core tip.mp3
Biostatistics Review Certificate	51881-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	51881-Conflict-of-interest statement.pdf
Copyright License Agreement	51881-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	51881-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	51881-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	51881-Language certificate.pdf
Peer-review Report	51881-Peer-review(s).pdf
Scientific Misconduct Check	51881-Scientific misconduct check.pdf
Scientific Editor Work List	51881-Scientific editor work list.pdf
CrossCheck Report	51881-CrossCheck report.pdf