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Articles Published Processes
1/17/2020 4:08:25 AM | Browse: 560 | Download: 918
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Received |
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2019-11-08 01:30 |
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Peer-Review Started |
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2019-11-08 01:32 |
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To Make the First Decision |
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Return for Revision |
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2019-11-19 05:00 |
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Revised |
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2019-12-02 13:18 |
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Second Decision |
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2019-12-19 06:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-12-22 10:49 |
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Articles in Press |
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2019-12-22 10:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-12-30 02:09 |
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Typeset the Manuscript |
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2020-01-09 01:09 |
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Publish the Manuscript Online |
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2020-01-17 04:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Case Report |
| Article Title |
Excellent response of severe aplastic anemia to treatment of gut inflammation: A case report and review of the literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi-Chen Zhao, Li Zhao, Xiao-Yun Sun, Zeng-Shan Xu, Bo Ju, Fan-Jun Meng and Hong-Guo Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong-Guo Zhao, MD, Chief Doctor, Professor, Department of Hematology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. zhaohongguo6201@163.com |
| Key Words |
Case report; Severe aplastic anemia; Hematological response; Chronic gut inflammation; Comorbid disease; Etiological association |
| Core Tip |
Aberrant immune responses in aplastic anemia had been proposed to be triggered by altered gut microbiota, and our serendipitous finding that a 30-year-old male with refractory severe aplastic anemia had gained an inadvertently excellent hematological response following oral administration of mannitol and gentamycin provides convincing evidence to support the hypothetical but plausible pathogenic association. Several comorbid diseases on this patient ameliorated together with the hematological improvements, indicating commonly shared etiological associations between the comorbidities and aplastic anemia in a background consisting of altered gut microbiota, chronic intestinal inflammation, increased epithelial permeability and an autoimmune nature, instead of the adverse events of cyclosporine and iron overload. |
| Publish Date |
2020-01-17 04:08 |
| Citation |
Zhao XC, Zhao L, Sun XY, Xu ZS, Ju B, Meng FJ, Zhao HG. Excellent response of severe aplastic anemia by to treating treatment of gut inflammation: A case report and review of the literature. World J Clin Cases 2020; 8(2): 425-435 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i2/425.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i2.425 |
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