Publication Name	World Journal of Gastroenterology
Manuscript ID	51925
Country	Netherlands

Received	2019-10-16 11:43
Peer-Review Started	2019-10-16 11:43
To Make the First Decision
Return for Revision	2019-11-10 05:02
Revised	2019-12-04 09:37
Second Decision	2019-12-13 09:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-12-14 02:36
Articles in Press	2019-12-14 02:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-19 07:09
Publish the Manuscript Online	2019-12-20 10:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Trends in treatment and overall survival among patients with proximal esophageal cancer
Manuscript Source	Invited Manuscript
All Author List	Judith de Vos-Geelen, Sandra ME Geurts, Margreet van Putten, Liselot BJ Valkenburg-van Iersel, Heike I Grabsch, Nadia Haj Mohammad, Frank JP Hoebers, Chantal V Hoge, Paul M Jeene, Evelien JM de Jong, Hanneke WM van Laarhoven, Tom Rozema, Marije Slingerland, Vivianne CG Tjan-Heijnen, Grard AP Nieuwenhuijzen and Valery EPP Lemmens
ORCID	Author(s) ORCID Number Judith de Vos-Geelen http://orcid.org/0000-0003-2578-1766 Sandra ME Geurts http://orcid.org/0000-0002-4265-9968 Margreet van Putten http://orcid.org/0000-0002-9218-7639 Liselot BJ Valkenburg-van Iersel http://orcid.org/0000-0003-2925-9908 Heike I Grabsch http://orcid.org/0000-0001-9520-6228 Nadia Haj Mohammad http://orcid.org/0000-0002-4688-2921 Frank JP Hoebers http://orcid.org/0000-0002-4317-9181 Chantal V Hoge http://orcid.org/0000-0002-6481-8237 Paul M Jeene http://orcid.org/0000-0002-6106-0547 Evelien JM de Jong http://orcid.org/0000-0002-8590-2518 Hanneke WM van Laarhoven http://orcid.org/0000-0003-3546-9709 Tom Rozema http://orcid.org/0000-0003-3255-1213 Marije Slingerland http://orcid.org/0000-0002-4181-8656 Vivianne CG Tjan-Heijnen http://orcid.org/0000-0002-3935-7440 Grard AP Nieuwenhuijzen http://orcid.org/0000-0002-5837-5513 Valery EPP Lemmens http://orcid.org/0000-0002-4109-5734
Funding Agency and Grant Number
Corresponding Author	Judith de Vos-Geelen, MD, Doctor, Doctor, Department of Internal Medicine, Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, P. Debyelaan 25, Maastricht 6202 AZ, Netherlands. judith.de.vos@mumc.nl
Key Words	Esophagus; Esophageal cancer; Proximal; Cervical; Upper thoracic; Trends
Core Tip	Proximal esophageal cancer is a rare disease, accounting for only 10% of all esophageal cancer cases. Limited data on treatment and survival in this rare tumor have been published, restricting patient counseling. The present investigation is the largest population-based cohort study evaluating trends in treatment and survival in proximal esophageal cancer. This study represents daily clinical practice, showing improvement in overall survival in patients with non-metastatic proximal esophageal cancer, with a shift to non-surgical treatment.
Publish Date	2019-12-20 10:20
Citation	de Vos-Geelen J, Geurts SME, van Putten M, Valkenburg-van Iersel LBJ, Grabsch HI, Haj Mohammad N, Hoebers FJP, Hoge CV, Jeene PM, de Jong EJM, van Laarhoven HWM, Rozema T, Slingerland M, Tjan-Heijnen VCG, Nieuwenhuijzen GAP, Lemmens VEPP. Trends in treatment and overall survival among patients with proximal esophageal cancer. World J Gastroenterol 2019; 25(47): 6835-6846
URL	https://www.wjgnet.com/1007-9327/full/v25/i47/6835.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i47.6835

Full Article (PDF)	WJG-25-6835.pdf
Full Article (Word)	WJG-25-6835.docx
Manuscript File	51925-Review.docx
Answering Reviewers	51925-Answering reviewers.pdf
Audio Core Tip	51925-Audio core tip.mp3
Biostatistics Review Certificate	51925-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	51925-Conflict-of-interest statement.pdf
Copyright License Agreement	51925-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	51925-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	51925-Language certificate.pdf
Supplementary Material	51925-Supplementary material.pdf
Peer-review Report	51925-Peer-review(s).pdf
Scientific Misconduct Check	51925-Scientific misconduct check.pdf
Scientific Editor Work List	51925-Scientific editor work list.pdf
CrossCheck Report	51925-CrossCheck report.pdf