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Articles Published Processes
2/7/2020 1:14:54 PM | Browse: 917 | Download: 1309
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Received |
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2019-10-09 21:09 |
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Peer-Review Started |
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2019-10-09 21:10 |
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To Make the First Decision |
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Return for Revision |
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2019-12-05 22:31 |
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Revised |
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2019-12-20 05:20 |
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Second Decision |
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2020-01-06 11:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-08 17:16 |
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Articles in Press |
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2020-01-08 17:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-01-15 01:57 |
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Typeset the Manuscript |
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2020-02-05 05:58 |
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Publish the Manuscript Online |
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2020-02-07 13:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Li and Rui-Hua Shi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Postgraduate Research and Practice Innovation Program of Jiangsu Province |
KYCX18_0174 |
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| Corresponding Author |
Rui-Hua Shi, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Gastroenterology, Southeast University,Zhongda Hospital, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China. ruihuashi@126.com |
| Key Words |
Crohn’s disease; Microarray; lncRNACNN3-206; Gene regulation; Cell migration and invasion; miR-212 |
| Core Tip |
We described new findings on overexpression of lncRNACNN3-206 in intestinal lesions of Crohn’s disease (CD) patients by High throughput sequencing. Moreover, forced overexpression lncRNACNN3-206 led to apoptosis of Caco-2 and HT-29 cell lines. Since the 3'-end of lncRNACNN3-206 and the 3’-UTR of Caspase10 contain high affinity binding sites of miR-212, in which lncRNACNN3-206 regulated Caspase10 expression and cell apoptosis/invasion through sponging of miR-212. This mechanism was supported by results from cell lines and the mouse CD model. It was concluded that lncRNACNN3-206 may play a key role in CD pathogenesis, and it could be a therapeutic target for CD treatment. |
| Publish Date |
2020-02-07 13:14 |
| Citation |
Li N, Shi RH. lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease. World J Gastroenterol 2020; 26(5): 478-498 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i5/478.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i5.478 |
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