BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/7/2020 1:14:54 PM | Browse: 1207 | Download: 2218
 |
Received |
|
2019-10-09 21:09 |
|
Peer-Review Started |
|
2019-10-09 21:10 |
|
First Decision by Editorial Office Director |
|
2019-12-05 22:31 |
|
Return for Revision |
|
2019-12-05 22:31 |
|
Revised |
|
2019-12-20 05:20 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2020-01-06 11:30 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2020-01-08 17:16 |
|
Articles in Press |
|
2020-01-08 17:16 |
|
Edit the Manuscript by Language Editor |
|
2020-01-15 01:57 |
|
Typeset the Manuscript |
|
2020-02-05 05:58 |
|
Publish the Manuscript Online |
|
2020-02-07 13:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Li and Rui-Hua Shi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Postgraduate Research and Practice Innovation Program of Jiangsu Province |
KYCX18_0174 |
|
| Corresponding Author |
Rui-Hua Shi, MD, PhD, Academic Research, Chief Doctor, Professor, Department of Gastroenterology, Southeast University,Zhongda Hospital, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China. ruihuashi@126.com |
| Key Words |
Crohn’s disease; Microarray; lncRNACNN3-206; Gene regulation; Cell migration and invasion; miR-212 |
| Core Tip |
We described new findings on overexpression of lncRNACNN3-206 in intestinal lesions of Crohn’s disease (CD) patients by High throughput sequencing. Moreover, forced overexpression lncRNACNN3-206 led to apoptosis of Caco-2 and HT-29 cell lines. Since the 3'-end of lncRNACNN3-206 and the 3’-UTR of Caspase10 contain high affinity binding sites of miR-212, in which lncRNACNN3-206 regulated Caspase10 expression and cell apoptosis/invasion through sponging of miR-212. This mechanism was supported by results from cell lines and the mouse CD model. It was concluded that lncRNACNN3-206 may play a key role in CD pathogenesis, and it could be a therapeutic target for CD treatment. |
| Publish Date |
2020-02-07 13:14 |
| Citation |
Li N, Shi RH. lncRNACNN3-206 activates intestinal epithelial cells apoptosis and invasion by sponging miR-212, implication for Crohn's disease. World J Gastroenterol 2020; 26(5): 478-498 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i5/478.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i5.478 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
