Publication Name	World Journal of Gastroenterology
Manuscript ID	5194
Country	Spain

Received	2013-08-21 09:20
Peer-Review Started	2013-08-21 21:32
To Make the First Decision	2013-09-16 20:24
Return for Revision	2013-09-17 10:34
Revised	2013-09-28 17:29
Second Decision	2013-11-29 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-29 23:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-25 11:51
Publish the Manuscript Online	2014-04-04 15:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Adaptive immune response during hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Juan Ramón Larrubia, Elia Moreno-Cubero, Megha Uttam Lokhande, Silvia García-Garzón, Alicia Lázaro, Joaquín Miquel, Cristian Perna and Eduardo Sanz-de-Villalobos
Funding Agency and Grant Number	Funding Agency Grant Number “Instituto de Salud Carlos III”, Spain “European Regional Development Fund (ERDF), a way of making Europe”, E.U. PI12/00130 “Fundación de Investigación Médica Mutua Madrileña”, Spain 8922/2011 “Asociación de Hepatología Translacional”, Spain AHT-2010/01 (to Lokhande MU)
Corresponding Author	Juan Ramón Larrubia, MD, MSc, PhD, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre st, E-19002 Guadalajara, Spain. juan.larrubia@uah.es
Key Words	Hepatitis C; Adaptive immune response; Hepatitis C virus-specific cytotoxic T cells; Hepatitis C virus-specific T helper cells; T regs; Hepatitis C virus escape mutations; Anergy; Apoptosis; Chemotaxis
Core Tip	In the last few years, the knowledge about the role of adaptive immune response in hepatitis C pathogenesis has increased exponentially. This review summarizes our current understanding of the role of antigen-specific responses in hepatitis C virus (HCV) control and liver damage and discusses recent findings that identify costimulatory molecules modulation, apoptosis induction and chemokine regulation as major HCV mechanisms to evade immune control.
Publish Date	2014-04-04 15:11
Citation	Larrubia JR, Moreno-Cubero E, Lokhande MU, García-Garzón S, Lázaro A, Miquel J, Perna C, Sanz-de-Villalobos E. Adaptive immune response during hepatitis C virus infection. World J Gastroenterol 2014; 20(13): 3418-3430
URL	http://www.wjgnet.com/1007-9327/full/v20/i13/3418.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i13.3418

Full Article (PDF)	WJG-20-3418.pdf
Full Article (Word)	WJG-20-3418.doc
Manuscript File	5194-Review.doc
Answering Reviewers	5194-Answering reviewers.pdf
Copyright License Agreement	5194-Copyright assignment.pdf
Peer-review Report	5194-Peer review(s).pdf
Scientific Editor Work List	5194-Scientific editor work list.doc