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Articles Published Processes
1/17/2020 4:08:25 AM | Browse: 700 | Download: 1423
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Received |
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2019-10-16 13:10 |
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Peer-Review Started |
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2019-10-11 07:45 |
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To Make the First Decision |
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Return for Revision |
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2019-12-04 14:27 |
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Revised |
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2019-12-13 13:35 |
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Second Decision |
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2019-12-19 07:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-12-22 13:31 |
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Articles in Press |
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2019-12-22 13:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-12-26 02:14 |
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Typeset the Manuscript |
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2020-01-09 01:10 |
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Publish the Manuscript Online |
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2020-01-17 04:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Durable response to pulsatile icotinib for central nervous system metastases from EGFR-mutated non-small cell lung cancer: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Ying Li, Yu Xie, Ting-Ting Yu, Yong-Juan Lin and Zhen-Yu Yin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Key Project of Nanjing Health Bureau |
ZKX16031 |
| the Healthcare Project of Nanjing Science and Technology Committee |
201715020 |
| the Medical Key Science and Technology Development Project of Nanjing |
ZKX18014 |
| the Cadre Health Care Project of Jiangsu Province |
BJ18006 |
| the Cancer Research Funding of CSCO-Hausen |
Y-HS2019-5 |
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| Corresponding Author |
Zhen-Yu Yin, PhD, Attending Doctor, Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. lihuiying@njglyy.com |
| Key Words |
Non-small cell lung cancer; Central nervous system metastases; EGFR mutation; Pulsatile icotinib; Case report; |
| Core Tip |
Central nervous system (CNS) metastases are a catastrophic complication of non-small cell lung cancer (NSCLC) and always accompanied by poor prognosis. We report a patient who was diagnosed with CNS metastases from NSCLC with a targeted mutation in epidermal growth factor receptor. A standard dosage of icotinib (125 mg three times daily) was implemented but ineffective. So pulsatile icotinib (1125 mg every 3 d) was administered. This new strategy for administration resulted in complete remission of neurological symptoms, almost vanished lesions, and longer survival without notable side effects, providing a new alternative for the treatment of CNS metastases. |
| Publish Date |
2020-01-17 04:08 |
| Citation |
Li HY, Xie Y, Yu TT, Lin YJ, Yin ZY. Durable response to pulsatile icotinib for central nervous system metastases from EGFR-mutated non-small cell lung cancer: A case report. World J Clin Cases 2020; 8(2): 370-376 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i2/370.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i2.370 |
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