Publication Name	World Journal of Gastroenterology
Manuscript ID	5207
Country	Poland

Received	2013-08-22 09:55
Peer-Review Started	2013-08-22 20:58
To Make the First Decision	2013-10-14 21:23
Return for Revision	2013-10-19 16:31
Revised	2013-11-09 21:09
Second Decision	2014-01-02 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-02 12:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-06 02:12
Typeset the Manuscript	2014-03-28 12:13
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria
Manuscript Source	Invited Manuscript
All Author List	Joanna M Lotowska, Maria E Sobaniec-Lotowska, Sylwia B Bockowska and Dariusz M Lebensztejn
Funding Agency and Grant Number
Corresponding Author	Maria E Sobaniec-Lotowska, MD, PhD, Professor of Medicine, Department of Medical Pathomorphology, Medical University of Bialystok, Waszyngtona Street 13, 15269 Bialystok, Poland. maria.sobaniec-lotowska@umb.edu.pl
Key Words	Pediatric non-alcoholic steatohepatitis; Hepatocyte ultrastructure; Megamitochondria with crystalline inclusions; Foamy cytoplasm of hepatocytes
Core Tip	Our electron-microscopic analysis of liver bioptates, being the first known investigation into pediatric non-alcoholic steatohepatitis (NASH), revealed characteristic repetitive mitochondrial abnormalities within hepatocytes, mainly mitochondrial polymorphism in the form of megamitochondria, loss of cristae, and the presence of linear crystalline inclusions within the mitochondrial matrix of increased electron density, frequently accompanied by foamy cytoplasm. As the discovery of these morphological indices of hepatocyte injury may be very useful in the diagnosis of NASH in pediatric patients, the ultrastructural analysis of liver biopsy can be recommended as an effective diagnostic method.
Publish Date	2014-04-17 13:27
Citation	Lotowska JM, Sobaniec-Lotowska ME, Bockowska SB, Lebensztejn DM. Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria. World J Gastroenterol 2014; 20(15): 4335-4340
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4335.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4335

Full Article (PDF)	WJG-20-4335.pdf
Full Article (Word)	WJG-20-4335.doc
Manuscript File	5207-Review.doc
Answering Reviewers	5207-Answering reviewers.pdf
Copyright License Agreement	5207-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130821212842.doc
Non-Native Speakers of English Editing Certificate	5207-Language certificate.pdf
Peer-review Report	5207-Peer reviewers.pdf
Scientific Editor Work List	5207-Scientific editor work list.doc