Publication Name	World Journal of Gastroenterology
Manuscript ID	5208
Country	Germany

Received	2013-08-22 09:59
Peer-Review Started	2013-08-23 18:22
To Make the First Decision	2013-10-14 21:23
Return for Revision	2013-10-19 16:38
Revised	2013-11-17 13:31
Second Decision	2014-01-02 11:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-02 12:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-05 10:15
Publish the Manuscript Online	2014-03-18 14:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
Manuscript Source	Invited Manuscript
All Author List	Sajjad Khan, Silke Cameron, Martina Blaschke, Federico Moriconi, Naila Naz, Ahmad Amanzada, Giuliano Ramadori and Ihtzaz Ahmed Malik
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation Open Access Publication Funds of the Göttingen University
Corresponding Author	Dr. Ihtzaz Ahmed Malik, Clinic of Gastroenterology and Endocrinology, University Medical Center, Robert-Koch-Str. 40, 37075 Goettingen, Germany. i.malik@med.uni-goettingen.de
Key Words	Colorectal-cancer; KRAS; BRAF; CXCL1 (GROα); CXCL10 (IP-10); CXCL8 (IL-8); Tumor necrosis factor-γ; Interleukin-1β; Interferon-κ; siRNA
Core Tip	The presence of KRAS/BRAF mutations in advanced colorectal-cancer influences the efficacy of treatment. It is not known whether the composition of tumor-associated immune cells is influenced by the mutational status of the tumor. The results of our study show a higher expression of pro-angiogenic chemokines at basal level in mutated cell-lines, which was further up-regulated by cytokine treatment. Moreover, specific KRAS inhibition resulted in an increase of pro-angiogenic chemokines, mainly through the NF-?B pathway in wt (Caco2). Our findings point to the interconnection of tumor mutation and its microenvironment.
Publish Date	2014-03-18 14:14
Citation	Khan S, Cameron S, Blaschke M, Moriconi F, Naz N, Amanzada A, Ramadori G, Malik IA. Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines. World J Gastroenterol 2014; 20(11): 2979-2994
URL	http://www.wjgnet.com/1007-9327/full/v20/i11/2979.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i11.2979

Full Article (PDF)	WJG-20-2979.pdf
Full Article (Word)	WJG-20-2979.doc
Manuscript File	5208-Review.docx
Answering Reviewers	5208-Answering reviewers.pdf
Copyright License Agreement	5208-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5208-Language certificate.pdf
Peer-review Report	5208-Peer reviews.pdf
Scientific Editor Work List	5208-Scientific editor work list.doc