Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	52081
Country	Italy

Received	2019-10-15 16:01
Peer-Review Started	2019-10-15 16:02
To Make the First Decision	2019-12-12 00:36
Return for Revision	2019-12-12 02:38
Revised	2020-02-24 08:21
Second Decision	2020-02-27 09:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-03-01 23:19
Articles in Press	2020-03-01 23:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-01 03:33
Publish the Manuscript Online	2020-05-12 03:08

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad: The overlap of a theory of change and bioinformatics
Manuscript Source	Invited Manuscript
All Author List	Guglielmo M Trovato
ORCID	Author(s) ORCID Number Guglielmo M Trovato http://orcid.org/0000-0002-1168-1919
Funding Agency and Grant Number
Corresponding Author	Guglielmo M Trovato, MD, Professor, Department of Clinical and Experimental Medicine, the School of Medicine of the University of Catania, Policlinico Città Universitaria–Via Santa Sofia 78, Catania 95131, Italy. guglielmotrovato@unict.it
Key Words	Non-alcoholic fatty liver disease; Fatty liver; Arterial stiffness; Bioinformatics; Methodology of research;
Core Tip	Atherosclerosis and non-alcoholic fatty liver disease straddle a communal epidemiology, underlying mechanism and a clinical syndrome with protean manifestations, touching every organ in the body. Current therapeutic evidence supports the recommendation of addressing changes toward healthier lifestyles, including diet and physical exercise, in atherosclerosis and non-alcoholic fatty liver disease, even when defined only by non-invasive methodology. Pathway-based analysis are elucidating key molecular mechanisms underlying complex diseases addressing the joint effect and integrality as function unit of multiple genes, exploring large-scale “-omics” data. No element suggests, apart from naïve statistics, that one condition affects the other directly by any mechanism.
Publish Date	2020-05-12 03:08
Citation	Trovato GM. Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad: The overlap of a theory of change and bioinformatics. World J Gastrointest Pathophysiol 2020; 11(3): 57-63
URL	https://www.wjgnet.com/2150-5330/full/v11/i3/57.htm
DOI	https://dx.doi.org/10.4291/wjgp.v11.i3.57

Full Article (PDF)	WJGP-11-57.pdf
Full Article (Word)	WJGP-11-57.docx
Manuscript File	52081-Review.docx
Answering Reviewers	52081-Answering reviewers.pdf
Audio Core Tip	52081-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	52081-Conflict-of-interest statement.pdf
Copyright License Agreement	52081-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	52081-Language certificate.pdf
Peer-review Report	52081-Peer-review(s).pdf
Scientific Misconduct Check	52081-Scientific misconduct check.pdf
Scientific Editor Work List	52081-Scientific editor work list.pdf
CrossCheck Report	52081-CrossCheck report.pdf