| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ezekiel Maloney, Yak-Nam Wang, Ravneet Vohra, Helena Son, Stella Whang, Tatiana Khokhlova, Joshua Park, Kayla Gravelle, Stephanie Totten, Joo Ha Hwang and Donghoon Lee |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health, National Cancer Institute |
R01 CA188654 |
| National Institutes of Health, National Cancer Institute |
R01 CA154451 |
|
| Corresponding Author |
Donghoon Lee, PhD, Professor, Department of Radiology, University of Washington, SLU C256, 850 Republican Street, Seattle, WA 98195, United States. dhoonlee@uw.edu |
| Key Words |
Pancreatic adenocarcinoma; Multiparametric magnetic resonance imaging; Focused ultrasound; ; ; |
| Core Tip |
In a genetic model of pancreatic ductal adenocarcinoma, clinically translatable, quantitative magnetic resonance imaging methods of T2, glycosaminoglycan chemical exchange saturation transfer, and apparent diffusion coefficient mapping were effective in non-invasively characterizing the treatment effects of pulsed focused ultrasound treatment. Pulsed focused ultrasound treatment has already been shown to improve survival for patients with pancreatic ductal adenocarcinoma in an early clinical trial, and these complimentary magnetic resonance imaging methods could help to advance this promising therapy in larger clinical trials. |
| Publish Date |
2020-03-06 10:54 |
| Citation |
Maloney E, Wang YN, Vohra R, Son H, Whang S, Khokhlova T, Park J, Gravelle K, Totten S, Hwang JH, Lee D. Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma. World J Gastroenterol 2020; 26(9): 904-917 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i9/904.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i9.904 |
