| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Su Hyuk Ko, Jong Ik Jeon, HA Woo and Jung Mogg Kim |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, South Korea |
NRF-2018R1D1A1B07043350 |
|
| Corresponding Author |
Jung Mogg Kim, MD, PhD, Chairman, Director, Director, Doctor, Doctor, Full Professor, Professor, Department of Microbiology, Hanyang University College of Medicine, Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea. jungmogg@hanyang.ac.kr, Seoul 04763, South Korea. jungmogg@hanyang.ac.kr |
| Key Words |
Bacteroides fragilis enterotoxin; Dendritic cells; Heme oxygenase-1; Mitogen-activated protein kinases; Nrf2; Signaling |
| Core Tip |
Enterotoxigenic Bacteroides fragilis is associated with non-invasive diarrheal diseases, inflammatory bowel diseases, and colorectal cancers. Bacteroides fragilis enterotoxin (BFT) is responsible for these diseases. The present study demonstrated that signaling pathways involving ROS-mediated ERK, p38 MAPK and Nrf2 activation in dendritic cells are required for heme oxygenase-1 (HO-1) induction during exposure to BFT. This signaling pathway is different from our previous report that BFT upregulates HO-1 in intestinal epithelial cells via a p38 MAPK- and NF-κB-dependent pathway. Therefore, this is the first report concerning the effects of BFT on the HO-1 induction pathway in dendritic cells. |
| Publish Date |
2020-01-16 07:58 |
| Citation |
Ko SH, Jeon JI, Woo HA, Kim JM. Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway. World J Gastroenterol 2020; 26(3): 291-306 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i3/291.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i3.291 |
