Publication Name	World Journal of Diabetes
Manuscript ID	52389
Country	Australia

Received	2019-10-31 12:45
Peer-Review Started	2019-10-31 12:46
To Make the First Decision
Return for Revision	2019-12-04 22:18
Revised	2020-01-03 13:07
Second Decision	2020-01-18 07:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-28 18:01
Articles in Press	2020-01-28 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-02-18 02:29
Publish the Manuscript Online	2020-02-28 10:31

ISSN	1948-9358 (online)
Open Access	Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Systematic Reviews
Article Title	Effects of gender-affirming hormone therapy on insulin resistance and body composition in transgender individuals: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Cassandra Spanos, Ingrid Bretherton, Jeffrey D Zajac and Ada S Cheung
ORCID	Author(s) ORCID Number Cassandra Spanos http://orcid.org/0000-0002-0235-2750 Ingrid Bretherton http://orcid.org/0000-0002-7158-8804 Jeffrey D Zajac http://orcid.org/0000-0003-3933-5708 Ada S Cheung http://orcid.org/0000-0001-5257-5525
Funding Agency and Grant Number	Funding Agency Grant Number Australian Government National Health and Medical Research Council APP1143333 Endocrine Society of Australia Austin Medical Research Foundation Viertel Charitable Foundation Clinical Investigator Award VIERCI2017009 Royal Australasian College of Physicians Vincent Fairfax Family Foundation
Corresponding Author	Ada S Cheung, FRACP, MBBS, MD, PhD, Doctor, Senior Research Fellow, Department of Medicine (Austin Health), Australia; Department of Endocrinology, The University of Melbourne, 145 Studley Road, Heidelberg 3084, Victoria, Australia. adac@unimelb.edu.au
Key Words	Transgender persons; Insulin resistance; Body composition; Gender dysphoria; Metabolic syndrome;
Core Tip	Evidence in transgender men suggests that testosterone therapy increases lean mass, decreases fat mass and has no impact on insulin resistance. Evidence in transgender women suggests that feminising hormone therapy (estradiol, with or without anti-androgen agents) decreases lean mass, increases fat mass, and may worsen insulin resistance. There is a paucity of prospective controlled research, and existing prospective evidence is limited by small sample sizes, short follow up periods, and young cohorts of participants. Until further evidence is available, clinicians should aim to minimise risk by monitoring cardiovascular risk markers regularly in their patients and encouraging healthy lifestyle modifications.
Publish Date	2020-02-28 10:31
Citation	Spanos C, Bretherton I, Zajac JD, Cheung AS. Effects of gender-affirming hormone therapy on insulin resistance and body composition in transgender individuals: A systematic review. World J Diabetes 2020; 11(3): 66-77
URL	https://www.wjgnet.com/1948-9358/full/v11/i3/66.htm
DOI	https://dx.doi.org/10.4239/wjd.v11.i3.66

Full Article (PDF)	WJD-11-66.pdf
Full Article (Word)	WJD-11-66.docx
Manuscript File	52389-Review.docx
Answering Reviewers	52389-Answering reviewers.pdf
Audio Core Tip	52389-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	52389-Conflict-of-Interest Disclosure Form.pdf
Copyright License Agreement	52389-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	52389-Grant application form(s).pdf
Supplementary Material	52389-Supplementary material.pdf
Peer-review Report	52389-Peer-review(s).pdf
Scientific Misconduct Check	52389-Scientific misconduct check.pdf
Scientific Editor Work List	52389-Scientific editor work list.pdf