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2/6/2020 2:37:44 AM | Browse: 650 | Download: 694
Publication Name World Journal of Clinical Cases
Manuscript ID 52417
Country China
Received
2019-11-18 11:27
Peer-Review Started
2019-11-08 14:08
To Make the First Decision
Return for Revision
2019-12-12 00:32
Revised
2019-12-31 15:07
Second Decision
2020-01-06 09:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-08 17:14
Articles in Press
2020-01-08 17:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-15 00:01
Typeset the Manuscript
2020-02-04 00:56
Publish the Manuscript Online
2020-02-06 02:37
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Case Report
Article Title Complete response to trastuzumab and chemotherapy in recurrent urothelial bladder carcinoma with HER2 gene amplification: A case report
Manuscript Source Unsolicited Manuscript
All Author List Qi Jiang, Mi-Xue Xie and Xiao-Chen Zhang
ORCID
Author(s) ORCID Number
Qi Jiang http://orcid.org/0000-0002-5307-3129
Mi-Xue Xie http://orcid.org/0000-0001-9129-1947
Xiao-Chen Zhang http://orcid.org/0000-0002-7014-868X
Funding Agency and Grant Number
Funding Agency Grant Number
Zhejiang Natural Science Foundation-Zhejiang Mathematical and Physical Medical Association SY19H310001
Corresponding Author Xiao-Chen Zhang, MD, Associate Chief Physician, Chief Physician, Department of Medical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. zhangxiaochen@zju.edu.cn
Key Words Urothelial bladder carcinoma; Trastuzumab; Complete response; Next generation sequencing; HER2; Case report
Core Tip Urothelial bladder carcinoma (UBC) is the most common type of urinary system tumors. Approximately 25% of patients present de novo with metastatic disease affecting long-term survival. Although Cisplatin-based combination chemotherapy has become the standard first-line regimens for recurrent UBC patients, there are still no second- and third-line treatments for definite efficacy. HER2 gene amplification has been found in UBC patients, but there is not enough clinical evidence for incorporating trastuzumab for treatment of recurrent UBC. This case hinted that the recurrent UBC patient with HER2 gene amplification may benefit from targeted trastuzumab, and more cases in the future are needed to confirm our findings.
Publish Date 2020-02-06 02:37
Citation Jiang Q, Xie MX, Zhang XC. Complete response to trastuzumab and chemotherapy in recurrent urothelial bladder carcinoma with HER2 gene amplification: A case report. World J Clin Cases 2020; 8(3): 594-599
URL https://www.wjgnet.com/2307-8960/full/v8/i3/594.htm
DOI https://dx.doi.org/10.12998/wjcc.v8.i3.594
Full Article (PDF) WJCC-8-594.pdf
Full Article (Word) WJCC-8-594.docx
CARE Checklist–2016 52417-CARE-Checklist–2016-revision.pdf
Manuscript File 52417-Review_WangTQ.docx
Answering Reviewers 52417-Answering reviewers.pdf
Audio Core Tip 52417-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 52417-Conflict-of-interest statement.pdf
Copyright License Agreement 52417-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52417-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 52417-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 52417-Language certificate.pdf
Peer-review Report 52417-Peer-review(s).pdf
Scientific Misconduct Check 52417-Scientific misconduct check.pdf
Scientific Editor Work List 52417-Scientific editor work list.pdf