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12/6/2019 8:06:37 AM | Browse: 708 | Download: 1010
Publication Name World Journal of Gastroenterology
Manuscript ID 52439
Country/Territory United States
Received
2019-11-01 13:16
Peer-Review Started
2019-11-01 13:17
To Make the First Decision
Return for Revision
2019-11-22 02:34
Revised
2019-11-25 12:12
Second Decision
2019-11-28 09:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-29 04:06
Articles in Press
2019-11-29 04:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-12-02 10:45
Publish the Manuscript Online
2019-12-06 08:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions
Manuscript Source Invited Manuscript
All Author List Albert J Czaja
ORCID
Author(s) ORCID Number
Albert J Czaja http://orcid.org/0000-0002-5024-3065
Funding Agency and Grant Number
Corresponding Author Albert J Czaja, FAASLD, AGAF, FACG, FACP, MD, Emeritus Professor, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, United States. czaja.albert@mayo.edu
Key Words Autoimmune hepatitis; Pathogenesis; Epigenetics; Molecular mimicry; Epitope spread; Intestinal microbiome
Core Tip The next generation of management of autoimmune hepatitis will depend on clarification of the pathogenic sequence from susceptibility to triggering events to disease maintenance or escalation. Studies that move the pathogenesis of autoimmune hepatitis closer to its cause have the potential to replace blanket immunosuppressive regimens and even suggest strategies for prevention. Investigations that expand concepts of acquired epigenetic change in gene expression, pathogenic molecular mimicries, epitope spread, bystander activation, and intestinal dysbiosis may narrow the knowledge gap between environmental factors and disease occurrence and behavior. Protective as well as site-specific corrective interventions may emerge.
Publish Date 2019-12-06 08:06
Citation Czaja AJ. Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions. World J Gastroenterol 2019; 25(45): 6579-6606
URL https://www.wjgnet.com/1007-9327/full/v25/i45/6579.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i45.6579
Full Article (PDF) WJG-25-6579.pdf
Full Article (Word) WJG-25-6579.docx
Manuscript File 52439-Review.docx
Answering Reviewers 52439-Answering reviewers.pdf
Audio Core Tip 52439-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 52439-Conflict-of-interest statement.pdf
Copyright License Agreement 52439-Copyright license agreement.pdf
Peer-review Report 52439-Peer-review(s).pdf
Scientific Misconduct Check 52439-Bing-Tang JZ-2.png
Scientific Misconduct Check 52439-Scientific misconduct check.pdf
Scientific Editor Work List 52439-Scientific editor work list.pdf