BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/6/2019 8:06:37 AM | Browse: 893 | Download: 1343
 |
Received |
|
2019-11-01 13:16 |
|
Peer-Review Started |
|
2019-11-01 13:17 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2019-11-22 02:34 |
|
Revised |
|
2019-11-25 12:12 |
|
Second Decision |
|
2019-11-28 09:51 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2019-11-29 04:06 |
|
Articles in Press |
|
2019-11-29 04:06 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2019-12-02 10:45 |
|
Publish the Manuscript Online |
|
2019-12-06 08:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Albert J Czaja |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Albert J Czaja, FAASLD, AGAF, FACG, FACP, MD, Emeritus Professor, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, United States. czaja.albert@mayo.edu |
| Key Words |
Autoimmune hepatitis; Pathogenesis; Epigenetics; Molecular mimicry; Epitope spread; Intestinal microbiome |
| Core Tip |
The next generation of management of autoimmune hepatitis will depend on clarification of the pathogenic sequence from susceptibility to triggering events to disease maintenance or escalation. Studies that move the pathogenesis of autoimmune hepatitis closer to its cause have the potential to replace blanket immunosuppressive regimens and even suggest strategies for prevention. Investigations that expand concepts of acquired epigenetic change in gene expression, pathogenic molecular mimicries, epitope spread, bystander activation, and intestinal dysbiosis may narrow the knowledge gap between environmental factors and disease occurrence and behavior. Protective as well as site-specific corrective interventions may emerge. |
| Publish Date |
2019-12-06 08:06 |
| Citation |
Czaja AJ. Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions. World J Gastroenterol 2019; 25(45): 6579-6606 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i45/6579.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i45.6579 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
