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9/5/2014 2:44:00 PM | Browse: 383 | Download: 320
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 5247
Country of Manuscript Source Greece
Received
2013-08-25 12:13
Peer-Review Started
2013-08-25 21:00
To Make the First Decision
2013-10-14 14:17
Return for Revision
2013-10-19 17:12
Revised
2013-11-04 23:32
Second Decision
2013-11-15 19:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-16 01:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-11-29 17:54
Typeset the Manuscript
2014-01-27 15:26
Publish the Manuscript Online
2014-01-27 17:26
ISSN 2150-5349 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett’s esophagus
Manuscript Source Invited Manuscript
All Author List Panagiotis Tsibouris, Erasmia Vlachou and Peter Edward Thomas Isaacs
Funding Agency and Grant Number
Correspondence To Panagiotis Tsibouris, PhD, Consultant Gastroenterologist, Gastroenterology Department, NIMTS General Hospital, 29 Biskini Str, 15771 Zografou, 11521 Athens, Greece. tsibofam@yahoo.com
Keywords Esophageal adenocarcinoma; Barrett’s esophagus; Non-steroidal anti-inflammatory drugs; Aspirin; Statins; Cancer chemoprevention
Core Tip Esophageal adenocarcinoma remains a major burden upon health. Experimental studies have suggested that non-steroidal anti-inflammatory drugs and statins may have useful actions against esophageal cancer cells. This review of observational studies shows that non-steroidal anti-inflammatory drugs reduced adenocarcinoma incidence in patients with Barrett’s esophagus by 41%, while statins reduced the risk by 43%. The cancer preventive effect is enhanced in those patients taking a combination of non-steroidal anti-inflammatory drugs and statins (a 74% decrease). Non-steroidal anti-inflammatory drugs clearly have substantial potential for toxicity, while statins are rather safe drugs. Their combination offers promise for chemoprevention and further interventional studies are warranted.
Publish Date 2014-01-27 17:26
Citation Tsibouris P, Vlachou E, Isaacs PET. Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett’s esophagus. World J Gastrointest Phar-macol Ther 2014; 5(1): 27-39
Url http://www.wjgnet.com/2150-5349/full/v5/i1/27.htm
DOI http://dx.doi.org/10.4292/wjgpt.v5.i1.27
Full Article (PDF) WJGPT-5-27.pdf
Full Article (Word) WJGPT-5-27.doc
Manuscript File 5247-Review.doc
Answering Reviewers 5247-Answering reviewers.pdf
Copyright License Agreement 5247-Copyright assignment.pdf
Peer-review Report 5247-Peer review(s).pdf
Scientific Editor Work List 5247-Scientific editor work list.doc