Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	5247
Country	Greece

Received	2013-08-25 12:13
Peer-Review Started	2013-08-25 21:00
To Make the First Decision	2013-10-14 14:17
Return for Revision	2013-10-19 17:12
Revised	2013-11-04 23:32
Second Decision	2013-11-15 19:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:38
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-29 17:54
Typeset the Manuscript	2014-01-27 15:26
Publish the Manuscript Online	2014-01-27 17:26

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett’s esophagus
Manuscript Source	Invited Manuscript
All Author List	Panagiotis Tsibouris, Erasmia Vlachou and Peter Edward Thomas Isaacs
Funding Agency and Grant Number
Corresponding Author	Panagiotis Tsibouris, PhD, Consultant Gastroenterologist, Gastroenterology Department, NIMTS General Hospital, 29 Biskini Str, 15771 Zografou, 11521 Athens, Greece. tsibofam@yahoo.com
Key Words	Esophageal adenocarcinoma; Barrett’s esophagus; Non-steroidal anti-inflammatory drugs; Aspirin; Statins; Cancer chemoprevention
Core Tip	Esophageal adenocarcinoma remains a major burden upon health. Experimental studies have suggested that non-steroidal anti-inflammatory drugs and statins may have useful actions against esophageal cancer cells. This review of observational studies shows that non-steroidal anti-inflammatory drugs reduced adenocarcinoma incidence in patients with Barrett’s esophagus by 41%, while statins reduced the risk by 43%. The cancer preventive effect is enhanced in those patients taking a combination of non-steroidal anti-inflammatory drugs and statins (a 74% decrease). Non-steroidal anti-inflammatory drugs clearly have substantial potential for toxicity, while statins are rather safe drugs. Their combination offers promise for chemoprevention and further interventional studies are warranted.
Publish Date	2014-01-27 17:26
Citation	Tsibouris P, Vlachou E, Isaacs PET. Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett’s esophagus. World J Gastrointest Phar-macol Ther 2014; 5(1): 27-39
URL	http://www.wjgnet.com/2150-5349/full/v5/i1/27.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v5.i1.27

Full Article (PDF)	WJGPT-5-27.pdf
Full Article (Word)	WJGPT-5-27.doc
Manuscript File	5247-Review.doc
Answering Reviewers	5247-Answering reviewers.pdf
Copyright License Agreement	5247-Copyright assignment.pdf
Peer-review Report	5247-Peer review(s).pdf
Scientific Editor Work List	5247-Scientific editor work list.doc