Publication Name	World Journal of Gastroenterology
Manuscript ID	5253
Country	China

Received	2013-08-26 09:43
Peer-Review Started	2013-08-26 21:14
To Make the First Decision	2013-10-14 21:24
Return for Revision	2013-10-19 17:20
Revised	2013-11-13 17:25
Second Decision	2014-01-02 11:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-02 12:10
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-09 08:55
Typeset the Manuscript	2014-04-19 17:00
Publish the Manuscript Online	2014-05-07 10:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Autobiography
Article Title	Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells
Manuscript Source	Invited Manuscript
All Author List	Hang Yuan, Ai-Jun Li, Sen-Lin Ma, Long-Jiu Cui, Bin Wu, Lei Yin and Meng-Chao Wu
Funding Agency and Grant Number	Funding Agency Grant Number Eastern Hepatobiliary Surgery Hospital of the Second Military Medical University
Corresponding Author	Ai-Jun Li, MD, Department of the 2nd Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, No. 225, Changhai Road, Shanghai 200438, China. ajli62@gmail.com
Key Words	Hepatocellular carcinoma; Histone deacetylase inhibitors; Autophagy; Sorafenib; Chemoresistance
Core Tip	In this study, we investigated the antiproliferative effect of sorafenib in combination with the histone deacetylase inhibitor vorinostatin in human hepatoma cell lines (Hep3B, HepG2, and PLC/PRF/5). We also examined whether the combination therapy was enhanced by the inhibition of autophagy. Our results showed that the combination of vorinostat with sorafenib synergistically reduced cell proliferation in hepatocellular carcinoma cells by inducing apoptosis and cell cycle arrest. Synergistic changes in cell cycle and cell survival regulators were also observed.
Publish Date	2014-05-07 10:10
Citation	Yuan H, Li AJ, Ma SL, Cui LJ, Wu B, Yin L, Wu MC. Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells. World J Gastroenterol 2014; 20(17): 4953-4962
URL	http://www.wjgnet.com/1007-9327/full/v20/i17/4953.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i17.4953

Full Article (PDF)	WJG-20-4953.pdf
Full Article (Word)	WJG-20-4953.doc
Manuscript File	5253-Review.doc
Answering Reviewers	5253-Answering reviewers.pdf
Copyright License Agreement	5253-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5253-Language certificate.pdf
Peer-review Report	5253-Peer review(s).pdf
Scientific Editor Work List	5253-Scientific editor work list.doc