Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	5260
Country	Kuwait

Received	2013-08-26 10:29
Peer-Review Started	2013-08-26 14:00
To Make the First Decision	2013-09-09 14:27
Return for Revision	2013-09-11 17:28
Revised	2013-09-12 20:57
Second Decision	2013-09-18 10:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-18 11:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-28 16:36
Typeset the Manuscript	2013-10-23 19:11
Publish the Manuscript Online	2013-11-26 21:56

ISSN	2220-3176 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Role of chemokines and cytokines in the neuropathogenesis of African trypanosomiasis
Manuscript Source	Invited Manuscript
All Author List	Willias Masocha
Funding Agency and Grant Number
Corresponding Author	Willias Masocha, B Pharm (Hons), PhD, Associate Professor, Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait. masocha@hsc.edu.kw
Key Words	African trypanosomiasis; Chemokine; Cytokine; Central nervous system; Brain parenchyma; Cerebrospinal fluid; Neuroinvasion; Neuroinflammation; Neurological disturbances
Core Tip	Human African trypanosomiasis (HAT) or sleeping sickness, caused by Trypanosoma brucei spp., is staged into an early hemolymphatic stage and a late meningoencephalitic stage. During the late stage parasites, increased numbers/levels of white blood cells, cytokines and/or chemokines are found in the cerebrospinal fluid of patients. In this mini review, contemporary findings on how chemokines and cytokines, such as interferon-gamma (IFN-γ), TNF-α, C-X-C motif chemokine 8 (CXCL8) and CXCL10, are thought to play an important role in the central nervous system invasion by the parasites, inflammation and the neuropathology of the disease and what might be candidates to differentiate between early and late stage HAT are discussed.
Publish Date	2013-11-26 21:56
Citation	Masocha W. Role of chemokines and cytokines in the neuropathogenesis of African trypanosomiasis. World J Clin Infect Dis 2013; 3(4): 79-85
URL	http://www.wjgnet.com/2220-3176/full/v3/i4/79.htm
DOI	http://dx.doi.org/10.5495/wjcid.v3.i4.79

Full Article (PDF)	WJCID-3-79.pdf
Manuscript File	5260-Review.docx
Answering Reviewers	5260-Answering reviewers.pdf
Copyright License Agreement	5260-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	5260-Language certificate.pdf
Peer-review Report	5260-Peer review(s).pdf
Scientific Editor Work List	5260-Scientific editor work list.doc