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8/29/2014 8:05:00 PM | Browse: 1154 | Download: 1026
Publication Name World Journal of Clinical Infectious Diseases
Manuscript ID 5260
Country/Territory Kuwait
Received
2013-08-26 10:29
Peer-Review Started
2013-08-26 14:00
To Make the First Decision
2013-09-09 14:27
Return for Revision
2013-09-11 17:28
Revised
2013-09-12 20:57
Second Decision
2013-09-18 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-09-18 11:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-09-28 16:36
Typeset the Manuscript
2013-10-23 19:11
Publish the Manuscript Online
2013-11-26 21:56
ISSN 2220-3176 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Minireviews
Article Title Role of chemokines and cytokines in the neuropathogenesis of African trypanosomiasis
Manuscript Source Invited Manuscript
All Author List Willias Masocha
Funding Agency and Grant Number
Corresponding Author Willias Masocha, B Pharm (Hons), PhD, Associate Professor, Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait. masocha@hsc.edu.kw
Key Words African trypanosomiasis; Chemokine; Cytokine; Central nervous system; Brain parenchyma; Cerebrospinal fluid; Neuroinvasion; Neuroinflammation; Neurological disturbances
Core Tip Human African trypanosomiasis (HAT) or sleeping sickness, caused by Trypanosoma brucei spp., is staged into an early hemolymphatic stage and a late meningoencephalitic stage. During the late stage parasites, increased numbers/levels of white blood cells, cytokines and/or chemokines are found in the cerebrospinal fluid of patients. In this mini review, contemporary findings on how chemokines and cytokines, such as interferon-gamma (IFN-γ), TNF-α, C-X-C motif chemokine 8 (CXCL8) and CXCL10, are thought to play an important role in the central nervous system invasion by the parasites, inflammation and the neuropathology of the disease and what might be candidates to differentiate between early and late stage HAT are discussed.
Publish Date 2013-11-26 21:56
Citation Masocha W. Role of chemokines and cytokines in the neuropathogenesis of African trypanosomiasis. World J Clin Infect Dis 2013; 3(4): 79-85
URL http://www.wjgnet.com/2220-3176/full/v3/i4/79.htm
DOI http://dx.doi.org/10.5495/wjcid.v3.i4.79
Full Article (PDF) WJCID-3-79.pdf
Manuscript File 5260-Review.docx
Answering Reviewers 5260-Answering reviewers.pdf
Copyright License Agreement 5260-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate 5260-Language certificate.pdf
Peer-review Report 5260-Peer review(s).pdf
Scientific Editor Work List 5260-Scientific editor work list.doc