| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague–Dawley rats
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nasisorn Suksridechacin, Punnisa Kulwong, Siriporn Chamniansawat and Narongrit Thongon |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Burapha University through National Research Council of Thailand |
15/2562 |
|
| Corresponding Author |
Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand. narongritt@buu.ac.th |
| Key Words |
Adverse effect; Colon; Mg2+ absorption; Proton pump inhibitors-induced hypomagnesemia; Small intestine; |
| Core Tip |
Proton pump inhibitors (PPIs) induced hypomagnesemia (PPIH) has attracted attention in the past decade. Previous studies proposed that PPIH is a consequence of intestinal Mg2+ malabsorption. However, the effect of prolonged PPI administration on duodenal, jejunal, ileal, and colonic Mg2+ absorption is largely unknown. In this study, the rats received 20 mg/ kg·d subcutaneous omeprazole injection for 12 and 24 wk, which is comparable to 5 and 10 human years, respectively. Omeprazole injection induced hypomagnesemia with reduced urinary Mg2+ excretion. The rates of total, paracellular, and transcellular Mg2+ absorption reduced in the duodenum, jejunum, ilium, and colon were discovered in PPIH rats. |
| Publish Date |
2020-03-21 02:52 |
| Citation |
Nasisorn Suksridechacin, Punnisa Kulwong, Siriporn Chamniansawat, Narongrit Thongon. Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague–Dawley rats. World J Gastroenterol 2020; 26(11): 1142-1155 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i11/1142.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i11.1142 |
