Publication Name	World Journal of Gastroenterology
Manuscript ID	52713
Country	Italy

Received	2019-11-25 17:39
Peer-Review Started	2019-11-25 17:39
To Make the First Decision
Return for Revision	2019-12-23 13:41
Revised	2020-01-02 12:54
Second Decision	2020-02-07 11:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-02-09 16:39
Articles in Press	2020-02-09 16:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-02-14 02:31
Publish the Manuscript Online	2020-02-21 00:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Proteomic insights on the metabolism in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Laura Francesca Pisani, Manuela Moriggi, Cecilia Gelfi, Maurizio Vecchi and Luca Pastorelli
ORCID	Author(s) ORCID Number Laura Francesca Pisani http://orcid.org/0000-0002-9490-3723 Manuela Moriggi http://orcid.org/0000-0002-4718-0307 Cecilia Gelfi http://orcid.org/0000-0002-2996-6912 Maurizio Vecchi http://orcid.org/0000-0003-1558-8604 Luca Pastorelli http://orcid.org/0000-0002-2810-9951
Funding Agency and Grant Number	Funding Agency Grant Number Italy’s Ministero Italiano della Salute (Italian Ministry of Health Grant) GR-2016-02364736
Corresponding Author	Luca Pastorelli, DPhil, MD, Assistant Professor, Doctor, Doctor, Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, Piazza Malan, San Donato Milanese 20097, Italy. luca.pastorelli@unimi.it
Key Words	Proteomics; Inflammatory bowel disease; Cronh’s disease; Ulcerative colitis; Proteins; Biomarkers discovery
Core Tip	Patients' heterogeneity is a hallmark for inflammatory bowel diseases (IBD). Some patients present limited bowel involvement and a mild course of the disease, others develop very extensive, aggressive disease and variable response to therapy. In IBD, there is a great need of patient stratification and of new biomarkers as part of a personalized medicine approach to patient care. Biological therapies are more and more widely used for IBD patients, because of their efficacy in patient’s refractory to other drugs; still, biological treatments fail in 20%-40% of patients and, to date, no reliable clinical or molecular predictor of response to biological therapeutic strategy has been described. This review aims to collect the "omics" approach for research of serological biomarkers of diagnosis, response to specific biological therapies in the IBD field.
Publish Date	2020-02-21 00:51
Citation	Pisani LF, Moriggi M, Gelfi C, Vecchi M, Pastorelli L. Proteomic insights on the metabolism in inflammatory bowel disease. World J Gastroenterol 2020; 26(7): 696-705
URL	https://www.wjgnet.com/1007-9327/full/v26/i7/696.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i7.696

Full Article (PDF)	WJG-26-696.pdf
Full Article (Word)	WJG-26-696.docx
Manuscript File	52713-Review.docx
Answering Reviewers	52713-Answering reviewers.pdf
Audio Core Tip	52713-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	52713-Conflict-of-interest statement.pdf
Copyright License Agreement	52713-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	52713-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	52713-Language certificate.pdf
Peer-review Report	52713-Peer-review(s).pdf
Scientific Misconduct Check	52713-Scientific misconduct check.pdf
Scientific Editor Work List	52713-Scientific editor work list.pdf
CrossCheck Report	52713-CrossCheck report.pdf