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3/26/2020 3:19:09 AM | Browse: 106 | Download: 180
Publication Name World Journal of Clinical Cases
Manuscript ID 52812
Country/Territory China
Received
2019-11-22 13:38
Peer-Review Started
2019-11-22 13:47
To Make the First Decision
Return for Revision
2019-12-12 00:21
Revised
2020-02-19 13:09
Second Decision
2020-02-27 07:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-28 06:43
Articles in Press
2020-02-28 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-03-04 21:58
Typeset the Manuscript
2020-03-13 08:36
Publish the Manuscript Online
2020-03-26 03:19
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology and Pharmacy
Manuscript Type Retrospective Study
Article Title Ruxolitinib add-on in corticosteroid-refractory graft-vs-host disease after allogeneic stem cell transplantation: Results from a retrospective study on 38 Chinese patients
Manuscript Source Unsolicited Manuscript
All Author List Si-Hua Dang, Qin Liu, Rong Xie, Na Shen, Shu Zhou, Wei Shi, Wen Liu, Ping Zou, Yong You and Zhao-Dong Zhong
ORCID
Author(s) ORCID Number
Si-Hua Dang http://orcid.org/0000-0002-9610-4597
Qin Liu http://orcid.org/0000-0003-2140-6790
Rong Xie http://orcid.org/0000-0002-4159-5069
Na Shen http://orcid.org/0000-0003-1642-9146
Shu Zhou http://orcid.org/0000-0002-1171-7969
Wei Shi http://orcid.org/0000-0002-4786-2164
Wen Liu http://orcid.org/0000-0003-3005-1485
Ping Zou http://orcid.org/0000-0001-7984-2216
Yong You http://orcid.org/0000-0001-8499-3799
Zhao-Dong Zhong http://orcid.org/0000-0001-5684-3478
Funding Agency and Grant Number
Corresponding author Zhao-Dong Zhong, MD, Doctor, Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Hankou District, Wuhan 430030, Hubei Province, China. whxhzzd008@126.com
Key Words Graft-vs-host disease; Graft-vs-leukemia effect; Allogeneic hematopoietic stem cell transplantation; Ruxolitinib; Treatment; Antifungal drugs
Core Tip This study aimed to investigate the effect and safety of ruxolitinib add-on in the treatment of patients with steroid-refractory (SR) acute (a) and chronic (c) graft-vs-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. An important finding of this retrospective case series was that the use of ruxolitinib as a salvage therapy for SR-GVHD resulted in an overall response rate of 100% in patients with SR-aGVHD (complete response: 80%) and 82.1% in patients with SR-cGVHD (complete response: 10.7%). In addition, this was achieved with a lower dose (5-10 mg/d) of ruxolitinib than previous reports, indicating that the dose of ruxolitinib could be lowered when used in combination with antifungal drugs (CYP2C9/CYP3A4 inhibitors).
Publish Date 2020-03-26 03:19
Citation Dang SH, Liu Q, Xie R, Shen N, Zhou S, Shi W, Liu W, Zou P, You Y, Zhong ZD. Ruxolitinib add-on in corticosteroid-refractory graft-vs-host disease after allogeneic stem cell transplantation: Results from a retrospective study on 38 Chinese patients. World J Clin Cases 2020; 8(6): 1065-1073
Url https://www.wjgnet.com/2307-8960/full/v8/i6/1065.htm
DOI https://dx.doi.org/10.12998/wjcc.v8.i6.1065
Full Article (PDF) WJCC-8-1065.pdf
Full Article (Word) WJCC-8-1065.docx
Manuscript File 52812-Review-Filipodia.docx
Answering Reviewers 52812-Answering reviewers.pdf
Audio Core Tip 52812-Audio core tip.m4a
Biostatistics Review Certificate 52812-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52812-Conflict-of-interest statement.pdf
Copyright License Agreement 52812-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 52812-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 52812-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52812-Language certificate.pdf
Peer-review Report 52812-Peer-review(s).pdf
Scientific Misconduct Check 52812-Scientific misconduct check.pdf
Scientific Editor Work List 52812-Scientific editor work list.pdf