Publication Name	World Journal of Gastroenterology
Manuscript ID	53063
Country	Norway

Received	2019-12-03 17:21
Peer-Review Started	2019-12-03 17:23
To Make the First Decision
Return for Revision	2020-01-13 18:24
Revised	2020-03-12 01:33
Second Decision	2020-03-12 12:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-03-14 05:09
Articles in Press	2020-03-14 05:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-03 06:33
Publish the Manuscript Online	2020-04-07 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Magdy El-Salhy
ORCID	Author(s) ORCID Number Magdy El-Salhy http://orcid.org/0000-0003-3398-3288
Funding Agency and Grant Number
Corresponding Author	Magdy El-Salhy, BSc, MA, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Section for Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, Stord 54 09, Norway. magdy.el-salhy@helse-fonna.no
Key Words	Diet; Gut enteroendocrine cells; Gut microbiota; Low grade inflammation; Stress;
Core Tip	The pathophysiology of irritable bowel syndrome (IBS) is not completely understood. Understanding the pathophysiology of IBS may enable us to find an effective treatment for this disorder. The density of intestinal stem cells is low in patients with IBS. Moreover, the differentiation of stem cells into enteroendocrine cells is abnormal. It seems that these abnormalities in intestinal stem cells is the cause of the low density of enteroendocrine cells seen in patients with IBS. It is believed that the low density of enteroendocrine cells is behind the gastrointestinal dysmotility, abnormal secretion/absorption and hypersensitivity observed in patients with IBS. This review presents the observations that suggest that the factors known to contribute to the pathophysiology of IBS may exert their effects through affecting the intestinal stem cells.
Publish Date	2020-04-07 14:46
Citation	El-Salhy M. Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome. World J Gastroenterol 2020; 26(13): 1427-1438
URL	https://www.wjgnet.com/1007-9327/full/v26/i13/1427.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i13.1427

Full Article (PDF)	WJG-26-1427.pdf
Full Article (Word)	WJG-26-1427.docx
Manuscript File	53063-Review.docx
Answering Reviewers	53063-Answering reviewers.pdf
Audio Core Tip	53063-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	53063-Conflict-of-interest statement.pdf
Copyright License Agreement	53063-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	53063-Language certificate.pdf
Peer-review Report	53063-Peer-review(s).pdf
Scientific Misconduct Check	53063-Scientific misconduct check.pdf
Scientific Editor Work List	53063-Scientific editor work list.pdf
CrossCheck Report	53063-CrossCheck Report.pdf