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Articles Published Processes
4/7/2020 2:46:34 PM | Browse: 943 | Download: 1885
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Received |
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2019-12-20 02:43 |
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Peer-Review Started |
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2019-12-16 07:27 |
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To Make the First Decision |
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Return for Revision |
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2020-02-18 22:52 |
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Revised |
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2020-03-06 08:55 |
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Second Decision |
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2020-03-18 11:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-19 00:53 |
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Articles in Press |
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2020-03-19 00:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-03-27 01:57 |
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Typeset the Manuscript |
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2020-04-05 05:54 |
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Publish the Manuscript Online |
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2020-04-07 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Satoyoshi Yamashita, Akira Kato, Toshitaka Akatsuka, Takashi Sawada, Tomohide Asai, Noriyuki Koyama and Kiwamu Okita |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kiwamu Okita, MD, PhD, Director, Director, Department of Internal Medicine, Shunan Memorial Hospital, Ikunoya Minami 1-10-1, Kudamatsu 7440033, Yamaguchi, Japan. okita@hcsdojinkai.or.jp |
| Key Words |
Serum preneoplastic antigen; Hepatitis C virus; Hepatocellular carcinoma; Des-γ-carboxy-prothrombin; α-Fetoprotein; Sensitivity |
| Core Tip |
Despite advances in treatment modalities and diagnosis, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is important to identify useful markers for the early detection of HCC. Preneoplastic antigen (PNA) is increased in tissues and serum of HCC patients. Therefore, we investigated the diagnostic value of PNA to discriminate HCC. We found that PNA had a comparable diagnostic value to α-fetoprotein and des-γ-carboxy-prothrombin. PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed, but α-fetoprotein or des-γ-carboxy-prothrombin is weakly or negatively expressed. |
| Publish Date |
2020-04-07 14:46 |
| Citation |
Yamashita S, Kato A, Akatsuka T, Sawada T, Asai T, Koyama N, Okita K. Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma. World J Gastroenterol 2020; 26(13): 1463-1473 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i13/1463.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i13.1463 |
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