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4/7/2020 2:46:34 PM | Browse: 828 | Download: 1460
Publication Name World Journal of Gastroenterology
Manuscript ID 53066
Country Japan
Received
2019-12-20 02:43
Peer-Review Started
2019-12-16 07:27
To Make the First Decision
Return for Revision
2020-02-18 22:52
Revised
2020-03-06 08:55
Second Decision
2020-03-18 11:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-19 00:53
Articles in Press
2020-03-19 00:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-03-27 01:57
Typeset the Manuscript
2020-04-05 05:54
Publish the Manuscript Online
2020-04-07 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Clinical and Translational Research
Article Title Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Satoyoshi Yamashita, Akira Kato, Toshitaka Akatsuka, Takashi Sawada, Tomohide Asai, Noriyuki Koyama and Kiwamu Okita
ORCID
Author(s) ORCID Number
Satoyoshi Yamashita http://orcid.org/0000-0002-7795-9960
Akira Kato http://orcid.org/0000-0002-2242-2787
Toshitaka Akatsuka http://orcid.org/0000-0002-3719-1205
Takashi Sawada http://orcid.org/0000-0002-6055-8183
Tomohide Asai http://orcid.org/0000-0002-7878-1404
Noriyuki Koyama http://orcid.org/0000-0002-7509-6583
Kiwamu Okita http://orcid.org/0000-0001-7368-8609
Funding Agency and Grant Number
Corresponding Author Kiwamu Okita, MD, PhD, Director, Department of Internal Medicine, Shunan Memorial Hospital, Ikunoya Minami 1-10-1, Kudamatsu 7440033, Yamaguchi, Japan. okita@hcsdojinkai.or.jp
Key Words Serum preneoplastic antigen; Hepatitis C virus; Hepatocellular carcinoma; Des-γ-carboxy-prothrombin; α-Fetoprotein; Sensitivity
Core Tip Despite advances in treatment modalities and diagnosis, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is important to identify useful markers for the early detection of HCC. Preneoplastic antigen (PNA) is increased in tissues and serum of HCC patients. Therefore, we investigated the diagnostic value of PNA to discriminate HCC. We found that PNA had a comparable diagnostic value to α-fetoprotein and des-γ-carboxy-prothrombin. PNA may have the potential to diagnose a novel type of HCC in which glutamyl transpeptidase is positively expressed, but α-fetoprotein or des-γ-carboxy-prothrombin is weakly or negatively expressed.
Publish Date 2020-04-07 14:46
Citation Yamashita S, Kato A, Akatsuka T, Sawada T, Asai T, Koyama N, Okita K. Clinical relevance of increased serum preneoplastic antigen in hepatitis C-related hepatocellular carcinoma. World J Gastroenterol 2020; 26(13): 1463-1473
URL https://www.wjgnet.com/1007-9327/full/v26/i13/1463.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i13.1463
Full Article (PDF) WJG-26-1463.pdf
Full Article (Word) WJG-26-1463.docx
Manuscript File 53066-Review-Webster J.docx
Answering Reviewers 53066-Answering reviewers.pdf
Audio Core Tip 53066-Audio core tip.mp3
Biostatistics Review Certificate 53066-Biostatistics statement.PDF
Conflict-of-Interest Disclosure Form 53066-Conflict-of-interest statement.pdf
Copyright License Agreement 53066-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 53066-Informed consent statement.PDF
Institutional Review Board Approval Form or Document 53066-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate 53066-Language certificate.pdf
Peer-review Report 53066-Peer-review(s).pdf
Scientific Misconduct Check 53066-Scientific misconduct check.pdf
Scientific Editor Work List 53066-Scientific editor work list.pdf