Publication Name	World Journal of Gastroenterology
Manuscript ID	5311
Country	Italy

Received	2013-08-29 08:50
Peer-Review Started	2013-08-29 15:52
To Make the First Decision	2013-09-27 16:46
Return for Revision	2013-09-29 15:15
Revised	2013-10-16 22:11
Second Decision	2013-10-21 17:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-10-22 06:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-23 15:46
Publish the Manuscript Online	2013-12-11 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases
Manuscript Source	Invited Manuscript
All Author List	Sara De Iudicibus, Marianna Lucafò, Stefano Martelossi, Chiara Pierobon, Alessandro Ventura and Giuliana Decorti
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health 44/GR-2010-2300447
Corresponding Author	Giuliana Decorti, MD, Department of Life Sciences, University of Trieste, via Fleming 22, I-34127 Trieste, Italy. decorti@units.it
Key Words	Glucocorticoids; Inflammatory bowel diseases; MicroRNA; Molecular markers; Pharmacogenomics
Core Tip	Studies on microRNAs (miRNAs) and pharmacogenomics represent a promising investigation topic that could increase the understanding of the pharmacology of steroids in inflammatory bowel diseases (IBDs) and possibly in other diseases. A number of studies have shown that glucocorticoids (GCs) can modify the expression profiles of different miRNAs, however, the obtained results have been highly variable, and to date it is not possible to recognize a specific miRNA pattern regulated by GCs. Moreover, existing studies employed techniques based on the use of reverse transcription quantitative polymerase chain reaction and microarrays, through the analysis and quantification of already known miRNAs. Using next generation sequencing technologies, it could be possible to detect novel, still unrecognised miRNAs, and identify new miRNA isoforms (iso-miRs) as well. This innovative approach could be a valuable tool for a better understanding of the role of miRNAs to predict steroid response in IBDs. In the future, the increased availability and the reduced costs of RNA profiling should enable the clinicians to stratify patients on specific miRNA biomarkers before starting GC treatment.
Publish Date	2013-12-11 16:13
Citation	De Iudicibus S, Lucafò M, Martelossi S, Pierobon C, Ventura A, Decorti G. MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases. World J Gastroenterol 2013; 19(44): 7947-7954
URL	http://www.wjgnet.com/1007-9327/full/v19/i44/7947.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i44.7947

Full Article (PDF)	WJG-19-7947.pdf
Manuscript File	5311-Review.doc
Answering Reviewers	5311-Answering Reviewers.pdf
Copyright License Agreement	5311-Copyright Assignmnet.pdf
Peer-review Report	5311-Peer Review(s).pdf
Scientific Editor Work List	5311-Scientific editor work list.doc