Publication Name	World Journal of Gastroenterology
Manuscript ID	5314
Country	China

Received	2013-08-29 09:01
Peer-Review Started	2013-08-29 16:01
To Make the First Decision	2013-10-22 16:52
Return for Revision	2013-10-22 17:35
Revised	2013-11-04 17:24
Second Decision	2014-05-29 20:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:59
Articles in Press	2014-05-29 21:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-25 08:54
Typeset the Manuscript	2014-07-25 14:02
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Xiao-Hua Zhang, Min-Li Li, Bin Wang, Mei-Xia Guo and Ren-Min Zhu
Funding Agency and Grant Number	Funding Agency Grant Number Funding from Jinling Hospital
Corresponding Author	Dr. Xiao-Hua Zhang, Department of Gastroenterology, Jinling Hospital, 305 Zhongshan Donglu, Nanjing 210002, Jiangsu Province, China. jszhxh@sina.com
Key Words	Severe acute pancreatitis; Caspase-1; Interleukin-1?; Interleukin-18; Acute renal injury
Core Tip	Activation of caspase-1/interleukin (IL)-1?-converting-enzyme (ICE) and the over-production of IL-18 and IL-1? in the kidney play a pivotal role during the process of acute renal injury in severe acute pancreatitis. Furthermore, ICE inhibitors are effective in improving renal function. The mechanisms of ICE inhibition may be associated with descended cytokine mediated injury and decreased renal cell apoptosis. Therefore, the study of the mechanism of acute renal injury in severe acute pancreatitis may help identify measures for the prevention and treatment, as well as supply novel information to further our understanding of systemic inflammatory response syndrome and multiple system organ failure.
Publish Date	2014-08-18 16:49
Citation	Zhang XH, Li ML, Wang B, Guo MX, Zhu RM. Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis. World J Gastroenterol 2014; 20(30): 10457-10463
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10457.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10457

Full Article (PDF)	WJG-20-10457.pdf
Full Article (Word)	WJG-20-10457.doc
Manuscript File	5314-Review.docx
Answering Reviewers	5314-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20130828195420.doc
Copyright License Agreement	5314-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130828195237.pdf
Non-Native Speakers of English Editing Certificate	5314-Language certificate.pdf
Peer-review Report	5314-Peer review(s).pdf
Scientific Misconduct Check	5314-CrossCheck.jpg
Scientific Editor Work List	5314-Scientific editor work list.pdf