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Articles Published Processes
4/14/2020 12:30:24 PM | Browse: 785 | Download: 1980
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Received |
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2019-12-10 16:03 |
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Peer-Review Started |
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2019-12-07 14:55 |
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To Make the First Decision |
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Return for Revision |
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2019-12-30 12:10 |
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Revised |
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2020-03-06 15:46 |
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Second Decision |
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2020-03-26 11:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-26 21:11 |
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Articles in Press |
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2020-03-26 21:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-13 09:40 |
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Publish the Manuscript Online |
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2020-04-14 12:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi and Alfredo Di Leo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alfredo Di Leo, MD, PhD, Full Professor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. alfredo.dileo@uniba.it |
| Key Words |
Intestinal cancer; Familial adenomatous polyposis; Chemopreventive diet; ApcMin/+ mice; Boswellia; Curcumin |
| Core Tip |
A dietetic formulation containing silymarin, boswellic acid and curcumin has shown “in vitro” and “in vivo” anti-carcinogenetic properties in animal model of inflammation-related intestinal carcinoma. Herein, we assessed whether it may prevent inherited intestinal cancer in animal model (adenomatous polyposis coli multiple intestinal neoplasia - ApcMin/+). Our results showed that the dietetic formulation reduced polypoid lesion number and size on autoptic tissue, histological dysplasia and neoplasia areas. This effect is related to increased epithelial renewal and apoptosis and decreased proliferation. Our data are suggestive of a chemo-preventive synergic effect of the components of the dietetic formulation in inherited intestinal carcinoma. |
| Publish Date |
2020-04-14 12:30 |
| Citation |
Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol 2020; 26(14): 1601-1612 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i14/1601.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i14.1601 |
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