| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen ≤ 1500 IU/mL: An observational study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng-Ping Wu, Ying Yang, Mei Li, Yi-Xin Liu, Ya-Ping Li, Wen-Jun Wang, Juan-Juan Shi, Xin Zhang, Xiao-Li Jia and Shuang-Suo Dang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31500650 |
|
| Corresponding Author |
Shuang-Suo Dang, MD, PhD, Academic Fellow, Academic Research, Doctor, Doctor, Professor, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an 710004, Shaanxi Province, China. dang212@126.com |
| Key Words |
Chronic hepatitis B; Peginterferon α-2a; Nucleos(t)ide analog; Hepatitis B surface antigen clearance; Hepatitis B surface antigen seroconversion; Add-on therapy |
| Core Tip |
Despite promising results with the combination therapy of Peg-interferon and Nucleos(t)ide analog (NA), the best combination therapeutic strategy of Peg-interferonand NA to the treatment of chronic hepatitis B remains unclear. This prospective study was to evaluate the efficacy and safety of add-on 48-wk of peginterferon α-2a to an ongoing NA regime in chronic hepatitis B patients with hepatitis B surface antigen levels ≤ 1500 IU/mL, hepatitis B e antigen-negative and hepatitis B virus-deoxyribonucleic acid < 1.0 × 102 IU/mL after over one year of NA therapy. |
| Publish Date |
2020-04-07 14:46 |
| Citation |
Wu FP, Yang Y, Li M, Liu YL, Li YP, Wang WJ, Shi JJ, Zhang X, Jia XL, Dang SS. Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen ≤ 1500 IU/mL: An observational study. World J Gastroenterol 2020; 26(13): 1525-1539 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i13/1525.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i13.1525 |
