Publication Name	World Journal of Transplantation
Manuscript ID	5322
Country	Brazil

Received	2013-08-29 09:31
Peer-Review Started	2013-08-29 16:54
To Make the First Decision	2013-09-09 14:29
Return for Revision	2013-09-11 10:30
Revised
Second Decision	2013-10-18 10:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-18 11:54
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-30 17:03
Publish the Manuscript Online	2013-12-31 17:17

ISSN	2220-3230 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Preclinical stem cell therapy in Chagas Disease: Perspectives for future research
Manuscript Source	Invited Manuscript
All Author List	Katherine Athayde Teixeira de Carvalho, Eltyeb Abdelwahid, Reginaldo Justino Ferreira, Ana Carolina Irioda and Luiz Cesar Guarita-Souza
Funding Agency and Grant Number
Corresponding Author	Katherine Athayde Teixeira de Carvalho, Professor, MD, PhD, Cell Therapy and Biotechnology in Regenerative Medicine Research Group, Pequeno Príncipe Faculty, Pelé Pequeno Príncipe Research Institute, Av. Siva Jardim 1632, Curitiba 80250-200, Paraná, Brazil. katherinecarv@gmail.com
Key Words	Chagas Disease; Preclinical; Stem cell; Therapy; Co-cultured; Translation; Pathophysiologie; Myoblasts
Core Tip	Core tip: The manuscript discusses examples that demonstrate how the results from preclinical trials might have overestimated the efficacy of myocardial regeneration with cell therapies, particularly in Chagas Disease and addressing the challenges associated with future research. The failure of cell therapy can be explained by crucial differences between the cellular types and pathophysiological mechanisms of the disease, as well as the differences between human patients and animal models.
Publish Date	2013-12-31 17:17
Citation	de Carvalho KAT, Abdelwahid E, Ferreira RJ, Irioda AC, Guarita-Souza LC. Preclinical stem cell therapy in Chagas Disease: Perspectives for future research. World J Transplant 2013; 3(4): 119-126
URL	http://www.wjgnet.com/2220-3230/full/v3/i4/119.htm
DOI	http://dx.doi.org/10.5500/wjt.v3.i4.119

Full Article (PDF)	WJT-3-119.pdf
Full Article (Word)	WJT-3-119.doc
Manuscript File	5322-Review.docx
Answering Reviewers	5322-Answering reviewers.pdf
Copyright License Agreement	5322-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5322-Language certificate.pdf
Peer-review Report	5322-Peer review(s).pdf
Scientific Editor Work List	5322-Scientific editor work list.doc