Publication Name	World Journal of Gastroenterology
Manuscript ID	5324
Country	China

Received	2013-08-30 09:33
Peer-Review Started	2013-08-30 13:34
To Make the First Decision	2013-11-13 14:15
Return for Revision	2013-09-17 21:22
Revised	2013-09-30 16:06
Second Decision	2013-12-06 14:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-06 14:46
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-11 17:19
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Xue-Qun Zhang, Cheng-Fu Xu, Chao-Hui Yu, Wei-Xing Chen and You-Ming Li
Funding Agency and Grant Number	Funding Agency Grant Number ational Key Basic Research Development Program 2012CB524905 National Science and Technology Support Plan Project 2012BAI06B04 National Natural Science Foundation of China 30900677 National Natural Science Foundation of China 81070315 National Natural Science Foundation of China 81070366 National Natural Science Foundation of China 81100278 National Natural Science Foundation of China 81170378 National Natural Science Foundation of China 81230012 National Natural Science Foundation of China 81270487 Zhejiang Provincial Natural Science Foundation of China Y2090463 Zhejiang Provincial Natural Science Foundation of China Y2110026 International Science and Technology Cooperation Projects of Zhejiang Province 2013C24010 Science Foundation of Health Bureau of Zhejiang Province 2009A070 Science Foundation of Health Bureau of Zhejiang Province 2012RCA026 Research Fund for the Doctoral Program of Higher Education of China (RFDP) 20090101120110
Corresponding Author	You-Ming Li, MD, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zhangxuequn720@163.com
Key Words	Endoplasmic reticulum stress; Unfolded protein response; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is a progressive disorder that can lead to impaired liver function and, ultimately, liver failure. Chronic endoplasmic reticulum stress induces numerous intracellular pathways that can lead to hepatic steatosis, systemic inflammation, and hepatocyte cell death, all of which are keystones of NAFLD. This review highlights the recent findings linking ER stress signaling pathways with the pathogenesis of NAFLD, which may help identify novel therapeutic targets for the prevention and treatment of NAFLD.
Publish Date	2014-03-12 11:24
Citation	Zhang XQ, Xu CF, Yu CH, Chen WX, Li YM. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(7): 1768-1776
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1768.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1768

Full Article (PDF)	WJG-20-1768.pdf
Full Article (Word)	WJG-20-1768.doc
Manuscript File	5324-Reivew.doc
Answering Reviewers	5324-Answering reviewers.pdf
Copyright License Agreement	5324-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5324-Language certificate.pdf
Peer-review Report	5324-Peer review(s).pdf
Scientific Editor Work List	5324-Scientific editor work list.doc