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Articles Published Processes
5/11/2020 9:58:04 AM | Browse: 1202 | Download: 2490
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Received |
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2019-12-18 13:15 |
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Peer-Review Started |
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2019-12-12 14:11 |
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First Decision by Editorial Office Director |
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2020-01-06 22:07 |
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Return for Revision |
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2020-01-06 22:07 |
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Revised |
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2020-03-16 20:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-03-30 15:14 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-03-30 21:09 |
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Articles in Press |
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2020-03-30 21:09 |
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Edit the Manuscript by Language Editor |
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2020-04-07 22:40 |
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Typeset the Manuscript |
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2020-05-09 03:35 |
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Publish the Manuscript Online |
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2020-05-11 09:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Maternal low protein diet induces persistent expression changes in metabolic genes in male rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Allan de Oliveira Lira, José Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, João Henrique da Costa-Silva, Béatrice Morio, Carol Góis Leandro and Luciano Pirola |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the CAPES/COFECUB |
797-14 |
| the National Council for Research – Brazil |
477915/2012-4 |
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| Corresponding Author |
Luciano Pirola, PhD, Senior Researcher, Carmen (Cardiology, Metabolism and Nutrition) Laboratory, INSERM U1060, Lyon-1 University，South Lyon Medical Faculty Sector 2, CENS ELI-2D building, 165 Chemin du grand Revoyet, Pierre Benite 69310, France. luciano.pirola@univ-lyon1.fr |
| Key Words |
Metabolic adaptation; Phenotype plasticity; Liver; Adipose tissue; Metabolism; Maternal protein undernutrition |
| Core Tip |
Perinatal exposure to a poor nutritional environment predisposes to metabolic disease. Here, the expression of metabolism-related genes in adipose tissue and liver was investigated. We evaluated the alterations in gene expression of glycolytic/Krebs cycle genes, adipogenic and lipolitic genes in adipose tissue of offspring rats at 30/90 d of age, exposed to maternal low-protein diet throughout gestation/lactation. We also evaluated expression of liver transcription factors and gluconeogenic genes. Persistent gene alterations were observed, that may account for the metabolic adaptations in response to maternal low-protein diet, highlighting the occurrence of persistent transcriptional defects as a consequence of perinatal malnutrition. |
| Publish Date |
2020-05-11 09:58 |
| Citation |
de Oliveira Lira A, de Brito Alves JL, Pinheiro Fernandes M, Vasconcelos D, Santana DF, da Costa-Silva JH, Morio B, Góis Leandro C, Pirola L. Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. World J Diabetes 2020; 11(5): 182-192 |
| URL |
https://www.wjgnet.com/1948-9358/full/v11/i5/182.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v11.i5.182 |
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