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Articles Published Processes
4/14/2020 12:30:24 PM | Browse: 837 | Download: 1524
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Received |
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2019-12-13 09:47 |
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Peer-Review Started |
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2019-12-13 09:47 |
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To Make the First Decision |
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Return for Revision |
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2020-01-16 21:42 |
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Revised |
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2020-01-22 09:13 |
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Second Decision |
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2020-03-11 14:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-14 05:10 |
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Articles in Press |
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2020-03-14 05:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-13 10:00 |
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Publish the Manuscript Online |
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2020-04-14 12:30 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Gastrointestinal cancer stem cells as targets for innovative immunotherapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mihaela Chivu-Economescu, Laura G Necula, Lilia Matei, Denisa Laura Dragu, Ana I Neagu, Irina Alexiu, Coralia Bleotu and Carmen Cristina Diaconu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Romanian National Authority for Scientific Research and Innovation, CNCS–UEFISCDI |
PN-III-P4-ID-PCCF2016-0158 |
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| Corresponding Author |
Mihaela Chivu-Economescu, PhD, Senior Researcher, Department of Cellular and Molecular Pathology, Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.economescu@virology.ro |
| Key Words |
Immunotherapy; Gastrointestinal cancer; Cancer stem cells; CAR-T; Dendritic cells vaccines; Immune checkpoints inhibitors |
| Core Tip |
Cancer immunotherapy has emerged in recent years as an alternative to classical anti-tumor therapy. It involves the activation of the host immune system in the fight against tumor cells, including cancer stem cells, which are responsible for tumor maintenance, relapse, and metastasis. Here we discuss the different forms of immunotherapy for gastrointestinal cancer stem cells targeting such as using monoclonal antibodies against surface antigens, generation of effector natural killer cells and T cells genetic engineered to target tumor antigens, dendritic vaccines, and immune checkpoints inhibitors. |
| Publish Date |
2020-04-14 12:30 |
| Citation |
Chivu-Economescu M, Necula LG, Matei L, Dragu DL, Neagu AI, Alexiu I, Bleotu C, Diaconu CC. Gastrointestinal cancer stem cells as targets for innovative immunotherapy. World J Gastroenterol 2020; 26(14): 1580-1593 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i14/1580.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i14.1580 |
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