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6/25/2020 10:09:17 AM | Browse: 38 | Download: 18
Publication Name World Journal of Stem Cells
Manuscript ID 53289
Country/Territory China
2020-01-15 10:40
Peer-Review Started
2020-01-15 10:41
To Make the First Decision
Return for Revision
2020-03-29 17:02
2020-04-17 15:05
Second Decision
2020-04-29 12:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-05 15:29
Articles in Press
2020-05-05 15:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-16 23:03
Typeset the Manuscript
2020-06-23 09:03
Publish the Manuscript Online
2020-06-25 10:09
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy
Manuscript Source Invited Manuscript
All Author List Bo-Duan Xiao, Yu-Jia Zhao, Fang Huang and Yi-Gang Wang
Author(s) ORCID Number
Bo-Duan Xiao http://orcid.org/0000-0003-0564-9944
Yu-Jia Zhao http://orcid.org/0000-0002-1032-8072
Fang Huang http://orcid.org/0000-0002-3115-8703
Yi-Gang Wang http://orcid.org/0000-0003-4546-8179
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Zhejiang Province of China LY18C070002
Natural Science Foundation of Zhejiang Province of China LY16H160056
National Natural Science Foundation of China 81803069
521 Talent Project of Zhejiang Sci-Tech University 18042291‐Y
Corresponding author Fang Huang, PhD, Assistant Professor, Department of pathology, Zhejiang Provincial People’s Hospital, Department of pathology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China, Hangzhou 310014, Zhejiang, China. huangfang0794@163.com
Keywords p21; CDKN1A; Tumorigenesis; Circular RNA; Stemness of tumor; Cancer stem cells; Tumor therapy
Core Tip p21, as a cyclin-dependent kinase regulator, suppresses cell cycle G1/S phase and retinoblastoma protein phosphorylation. As the downstream target gene of TP53, p21 expression is induced by wild-type p53. p21 was found as a tumor suppressor in several cancers by targeting p53 and was associated with tumorigenesis and metastasis. Notably, p21 is also associated with cancer stem cells. Moreover, p21 is closely related to cancer therapy, and it can promote antitumor effect of oncolytic virotherapy. It implicated multifaceted roles of p21 in cancer.
Publish Date 2020-06-25 10:09
Citation Xiao BD, Zhao YJ, Jia XY, Wu J, Wang YG, Huang F. Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy. World J Stem Cells 2020; 12(6): 481-487
Url https://www.wjgnet.com/1948-0210/full/v12/i6/481.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i6.481
Full Article (PDF) WJSC-12-481.pdf
Full Article (Word) WJSC-12-481.docx
Manuscript File 53289-Review-Ma JY.doc
Answering Reviewers 53289-Answering reviewers.pdf
Audio Core Tip 53289-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 53289-Conflict-of-interest statement.pdf
Copyright License Agreement 53289-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53289-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 53289-Language certificate.pdf
Peer-review Report 53289-Peer-review(s).pdf
Scientific Misconduct Check 53289-Scientific misconduct check.pdf
Scientific Editor Work List 53289-Scientific editor work list.pdf