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Articles Published Processes
6/25/2020 10:09:17 AM | Browse: 761 | Download: 1004
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Received |
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2020-01-15 10:40 |
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Peer-Review Started |
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2020-01-15 10:41 |
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To Make the First Decision |
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Return for Revision |
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2020-03-29 17:02 |
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Revised |
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2020-04-17 15:05 |
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Second Decision |
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2020-04-29 12:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-05-05 15:29 |
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Articles in Press |
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2020-05-05 15:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-05-16 23:03 |
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Typeset the Manuscript |
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2020-06-23 09:03 |
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Publish the Manuscript Online |
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2020-06-25 10:09 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bo-Duan Xiao, Yu-Jia Zhao, Fang Huang and Yi-Gang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province of China |
LY18C070002 |
| Natural Science Foundation of Zhejiang Province of China |
LY16H160056 |
| National Natural Science Foundation of China |
81803069 |
| 521 Talent Project of Zhejiang Sci-Tech University |
18042291‐Y |
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| Corresponding Author |
Fang Huang, PhD, Assistant Professor, Department of pathology, Zhejiang Provincial People’s Hospital, Department of pathology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China, Hangzhou 310014, Zhejiang Province, China. huangfang0794@163.com |
| Key Words |
p21; CDKN1A; Tumorigenesis; Circular RNA; Stemness of tumor; Cancer stem cells; Tumor therapy |
| Core Tip |
p21, as a cyclin-dependent kinase regulator, suppresses cell cycle G1/S phase and retinoblastoma protein phosphorylation. As the downstream target gene of TP53, p21 expression is induced by wild-type p53. p21 was found as a tumor suppressor in several cancers by targeting p53 and was associated with tumorigenesis and metastasis. Notably, p21 is also associated with cancer stem cells. Moreover, p21 is closely related to cancer therapy, and it can promote antitumor effect of oncolytic virotherapy. It implicated multifaceted roles of p21 in cancer. |
| Publish Date |
2020-06-25 10:09 |
| Citation |
Xiao BD, Zhao YJ, Jia XY, Wu J, Wang YG, Huang F. Multifaceted p21 in carcinogenesis, stemness of tumor and tumor therapy. World J Stem Cells 2020; 12(6): 481-487 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i6/481.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i6.481 |
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