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5/14/2020 10:35:45 AM | Browse: 874 | Download: 1644
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 53292
Country/Territory Brazil
Received
2019-12-13 16:48
Peer-Review Started
2019-12-13 16:48
To Make the First Decision
2020-01-14 06:48
Return for Revision
2020-01-14 07:52
Revised
2020-01-30 17:23
Second Decision
2020-04-04 06:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-05 16:19
Articles in Press
2020-04-05 16:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-17 00:58
Typeset the Manuscript
2020-05-13 00:07
Publish the Manuscript Online
2020-05-14 10:35
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer
Manuscript Source Invited Manuscript
All Author List Caroline de Matos Lourenço, Manoela Dias Susi, Mariah Cristina Antunes do Nascimento, Vilson Serafim Junior, Ana Paula Simedan Vila, Gabriela Helena Rodrigues-Fleming, Eny Maria Goloni-Bertollo, Ana Elizabete Silva and Juliana Garcia de Oliveira-Cucolo
ORCID
Author(s) ORCID Number
Caroline de Matos Lourenço http://orcid.org/0000-0003-3629-1447
Manoela Dias Susi http://orcid.org/0000-0001-7913-2564
Mariah Cristina Antunes do Nascimento http://orcid.org/0000-0002-6422-4068
Vilson Serafim Junior http://orcid.org/0000-0002-3349-0531
Ana Paula Simedan Vila http://orcid.org/0000-0003-4353-0696
Gabriela Helena Rodrigues-Fleming http://orcid.org/0000-0002-6714-6931
Eny Maria Goloni-Bertollo http://orcid.org/0000-0002-2622-4673
Ana Elizabete Silva http://orcid.org/0000-0003-1491-8878
Juliana Garcia de Oliveira-Cucolo http://orcid.org/0000-0002-2125-9930
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation 2013/14022-6
São Paulo Research Foundation 2014/17716-1
Corresponding Author Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University, Rua Cristóvão Colombo, 2265, São José do Rio Preto 15054-000, São Paulo, Brazil. anabete@ibilce.unesp.br
Key Words Toll-like receptor 2; Helicobacter pylori; Gastric cancer; Chronic gastritis; Polymorphisms; Gene expression
Core Tip This study showed that two polymorphisms in toll-like receptor-2 (TLR2) are strongly associated with gastric cancer and H. pylori infection in the Brazilian population. TLR2 mRNA expression was increased in gastric cancer tissue compared with chronic gastritis and normal tissues. Moreover, TLR2 mRNA expression levels were upregulated in gastric cancer in the presence of the TLR2 -196 to -174 del variant allele or the wild-type TLR2 19216 T allele and in the presence of H. pylori. Thus, gene polymorphisms that change expression levels, such as those in TLR2, may alter the immune response and, consequently, the development and clinical manifestations of cancer.
Publish Date 2020-05-14 10:35
Citation Lourenço CM, Susi MD, Nascimento MCA, Serafim Junior V, Vila APS, Rodrigues-Flemming GH, Goloni-Bertollo EM, Silva AE, Oliveira-Cucolo JG. Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer. World J Gastrointest Oncol 2020; 12(5): 535-548
URL https://www.wjgnet.com/1948-5204/full/v12/i5/535.htm
DOI https://dx.doi.org/10.4251/wjgo.v12.i5.535
Full Article (PDF) WJGO-12-535.pdf
Full Article (Word) WJGO-12-535.docx
STROBE Statement 53292-STROBE-Statement-revision.pdf
Manuscript File 53292-Review-Filipodia.doc
Answering Reviewers 53292-Answering reviewers.pdf
Audio Core Tip 53292-Audio core tip.mp3
Biostatistics Review Certificate 53292-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53292-Conflict-of-interest statement.pdf
Copyright License Agreement 53292-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53292-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 53292-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 53292-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 53292-Language certificate.pdf
Peer-review Report 53292-Peer-review(s).pdf
Scientific Misconduct Check 53292-Scientific misconduct check.pdf
Scientific Editor Work List 53292-Scientific editor work list.pdf