| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Caroline de Matos Lourenço, Manoela Dias Susi, Mariah Cristina Antunes do Nascimento, Vilson Serafim Junior, Ana Paula Simedan Vila, Gabriela Helena Rodrigues-Fleming, Eny Maria Goloni-Bertollo, Ana Elizabete Silva and Juliana Garcia de Oliveira-Cucolo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation |
2013/14022-6 |
| São Paulo Research Foundation |
2014/17716-1 |
|
| Corresponding Author |
Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University, Rua Cristóvão Colombo, 2265, São José do Rio Preto 15054-000, São Paulo, Brazil. anabete@ibilce.unesp.br |
| Key Words |
Toll-like receptor 2; Helicobacter pylori; Gastric cancer; Chronic gastritis; Polymorphisms; Gene expression |
| Core Tip |
This study showed that two polymorphisms in toll-like receptor-2 (TLR2) are strongly associated with gastric cancer and H. pylori infection in the Brazilian population. TLR2 mRNA expression was increased in gastric cancer tissue compared with chronic gastritis and normal tissues. Moreover, TLR2 mRNA expression levels were upregulated in gastric cancer in the presence of the TLR2 -196 to -174 del variant allele or the wild-type TLR2 19216 T allele and in the presence of H. pylori. Thus, gene polymorphisms that change expression levels, such as those in TLR2, may alter the immune response and, consequently, the development and clinical manifestations of cancer. |
| Publish Date |
2020-05-14 10:35 |
| Citation |
Lourenço CM, Susi MD, Nascimento MCA, Serafim Junior V, Vila APS, Rodrigues-Flemming GH, Goloni-Bertollo EM, Silva AE, Oliveira-Cucolo JG. Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer. World J Gastrointest Oncol 2020; 12(5): 535-548 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i5/535.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i5.535 |
