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Articles Published Processes
11/26/2020 10:14:32 AM | Browse: 536 | Download: 1430
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Received |
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2020-03-28 04:39 |
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Peer-Review Started |
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2020-03-30 08:48 |
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To Make the First Decision |
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Return for Revision |
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2020-07-05 15:18 |
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Revised |
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2020-07-07 03:14 |
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Second Decision |
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2020-09-08 10:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-09-08 20:36 |
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Articles in Press |
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2020-09-08 20:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-17 23:24 |
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Typeset the Manuscript |
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2020-11-25 06:05 |
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Publish the Manuscript Online |
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2020-11-26 10:14 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
AlCl3 exposure regulates neuronal development by modulating DNA modification
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xue-Jun Cheng, Fu-Lai Guan, Qian Li, Gong Dai, Hai-Feng Li and Xue-Kun Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China of the 13th Five-Year Plan |
2016YFC1306205 |
| Provincial Key Disciplines of Zhejiang Traditional Chinese Medicine (Combination of Traditional Chinese and Western medicine) |
2017-XK-A41 |
| National Natural Science Foundation of China |
31771395 |
| National Natural Science Foundation of China |
31571518 |
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| Corresponding Author |
Xue-Kun Li, PhD, Professor, The Institute of Translational Medicine, School of Medicine, Zhejiang University, No. 268 Kaixuan Road, Central North Building Room 440, Huajiachi Campus, Hangzhou 310029, Zhejiang Province, China. xuekun_li@zju.edu.cn |
| Key Words |
Aluminum; DNA demethylation; 5-hydroxymethylcytosine; Neural stem cells; Neuron; Neuronal development |
| Core Tip |
Although the neurotoxic effects of aluminum have been known, it is still unclear regarding the effects of aluminum on epigenetic modifications in the context of neuronal development. Our present study has revealed that aluminum exerts the neurotoxic effects including promoting cell death through regulating DNA modifications. These results highlight the crosstalk between the environment and epigenetics, and subsequent phenotypes. Our findings emphasize the importance of protecting the environment and improving food safety. |
| Publish Date |
2020-11-26 10:14 |
| Citation |
Cheng XJ, Guan FL, Li Q, Dai G, Li HF, Li XK. AlCl3 exposure regulates neuronal development through modulating DNA modification. World J Stem Cells 2020; 12(11): 1354-1365 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i11/1354.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i11.1354 |
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